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《Guizhou Agricultural Sciences》 2007-05
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The Effect of Lipopolysaccharide (LPS) Challenged by Two Histamine Receptor Antagonists on Body Temperature of Chicken

FU Xuezhi,OU Deyuan,XU Leren,LI Jinguo,TAN Jianmin(College of Animal Science,Guizhou University,Guiyang,Guizhou 550025,China)  
Two histamine receptor antagonists were tested to investigate its effect of lipopolysaccharide(LPS) on body temperature of chicken and the fever mechanism by the endogenous histamine.The results showed that in the acute test the body temperature of the chicken group injected by chlorpheniramine significantly dropped(P0.05) at 2h and 4h after injection and the body temperature of the chicken group injected by chlorpheniramine and cimetidine very significantly dropped(P0.01) at 2h after injection compared with CK,that in the chronic test there was no significant difference at 0d and 4d in the body temperature,the body temperature of the chicken group injected by chlorpheniramine significantly dropped(P0.05) at 10d and 15d after injection and the body temperature of the chicken group injected by chlorpheniramine and cimetidine significantly dropped(P0.05) at 15d after injection.The conclusion is that the endogenesis histamine raises the body temperature mainly by H1 acceptor in the inflammation induced by LPS.
【Fund】: 贵州省优秀人才基金项目“组胺在肺动脉高压综合症中的作用机理研究”[黔省专合字2005(349)]
【CateGory Index】: S858.31
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