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《Guizhou Agricultural Sciences》 2012-10
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Variation of MC1R Gene and Prediction of Protein Structure in Lueyang Silky Fowl

ZHANG Tao,LU Hongzhao,JIANG Hai,LI Lixia(School of Biological Sciences and Engineering,Shaanxi University of Technology,Hanzhong,Shaanxi 723000,China)  
To figure out the relationship between the nucleotide sequence of MC1R gene and the formation of melanin,the physicochemical property and molecular structure of Lueyang Silky Fowl were detected by PCR-SSCP and sequencing.The results showed that the variations of MC1R were very small in Lueyang chicken population,but there were seven single nucleotide mutations sites at the 69,212,274,376,636,637 and 644 locus of the coding region comparing with White Leghorn breed.Except 69 and 636 locus,the five mutational sites were resulted amino acid sequences changing,and leaded to adding a phosphorylation site in melanocortin receptor 1.All these mutations sites may be correlated with the production and precipitation of melanin in Lueyang Silky Fowl.Cluster analysis indicated that Lueyang Silky Fowl had close genetic relationship with jungle fowl,and had distance genetic relationship with leghorn.Lueyang Silky Fowl was a relatively old breed,and reserved original gene pool;MC1R gene was a major gene resistance regulating melanin trait in Lueyang Silky Fowl.
【Fund】: 陕西理工学院科研项目“略阳乌鸡黑色素合成候选基因鉴定研究”(SLGKY10-04)
【CateGory Index】: S831
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