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《Guangdong Medical Journal》 2001-05
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Study of expression of matrixmetalloproteinases in liver cirrhosis

Liu Jingzhang, Zhao Zilin, Gao Yi, et al. Department of Hepatobiliary, Zhujiang Hospital, First Military Medical University, Guangzhou 510282  
Objective To investigate the relationship between the expression of MMP-1 and MMP-2 in the liver and the development of liver cirrhosis.Methods Expression of MMP-1 and MMP-2 in the liver tissues of 39 patients was studied by Strept Acidin-Biotin-enzyme complex(SABC) immunohistochemistry and computer image analysis. Results Increase expression of matrix metalloproteinases was related to the cirrhosis of liver. In the cirrhotic tissue, the expression of MMP-2 was higher than that in normal tissue( P 0 01); MMP-1 expression in the verge of cirrhosis tissue was not significantly higher than that in normal tissue ( P 0 05).Conclusion Matrix metalloproteinases is one of the important factors influencing the development of cirrhosis of liver with different mechanism in MMP-1 and MMP-2.
【CateGory Index】: R363
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