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《Guangdong Medical Journal》 2004-01
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The relation between the lung pathology induced by lipopolysaccharide and neonatal pulmonary hemorrhage

Du Yue, Cai Xuxu, Han Yukun. Pediatric Department, Second Affiliated Hospital, China Medical University, Shenyang 110004  
Objective To investigate the pathophysiology of acute lung injury in newborn rats induced by lipopolysaccharide. Methods The changes of lung pathology in newborn rats was observed under microscope and transmission microscope after LPS was injected intraperitoneally. Results Pulmonary hemorrhage was observed in newborn rats injected with LPS. The pathology in newborn rats was characterized by the disruption of capillary basement membrane and later filtration of white blood cells, different from the changes of lung damaged induced by LPS in adult rats. Conclusion The animal model of pulmonary hemorrhage in newborn rats induce by LPS will be helpful for the research of neonatal pulmonary hemorrhage.
【CateGory Index】: R722.1
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