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《Journal of Engineering Thermophysics》 1988-02
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THE THEORETICAL AND ANIMAL EXPERIMENTAL STUDY OF THE TRANSIENT TEMPERATURE FIELD IN TISSUE DURING INTERSTITIAL PHOTODYNAMIC THERAPY

Wang Buxuan Cai Weiming Wu Yulong(Thermal Engineering Department, Tsinghua University The Cancer Research Institute of Chinese Academy of Medical Sciences)  
A method for computer-aid simulation to alculate the one-dimensional transient temperature field, the laser's penetrating depth in tissue and the change of blood perfusion during interstitial photodynamic therapy (IPDT) has been presented. Animal experiments had been conducted to check the predicted temperature field with discussions. In the case of adapting multi-fibres, the calculated results provide the selection of optimum distance between fibres and the effective radius of cure tumors. The method for the thermal analysis and the technique for diagnosis and control of the maximum temperature rise would be of practical- use to suit the primary needs of clinicians to get the maximum synorgistic effect using laser irradiation as a heater of hyperthermia during IPDT.
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