Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Anatomy Research》 2004-01
Add to Favorite Get Latest Update

Effect of Tortoises shell on behavior and striatum levels of dopamine in rat model of Parkinsons disease

Li Yiwei,Zhou Jianhong,Chen Dongfen,Li Hui,Du Shaohui.Guangzhou University of TCM,Guangzhou 510405 China  
Objective The effect of motor abnormalities and striatum levels of dopamine(DA) and its metabolites(DOPAC,HVA)were observed by Tortoises schell in a rat model of Parkinsons disease(PD).Methods 6-OHDA was stereostactically injected into the striatum of the rats to induce a rat model of PD.The injured rats were randomly divided into the experimental and the control group.The rotational behavior of the rats was determined and the content of dopamine,3,4-dihydroxyphenylacetic acid and homovaillic acid in the striatum of the rat model was analyzed at 4,8,12,16 weeks.Results Experimental group could substantially reduce the rotational behavior of PD rats.The levels of DA,DOPAC and HVA in the striatum of the experimental group increased to 3.12±0.48,0.27±0.06,and 0.35±0.06 respectively(P0.05,compared with control group).Conclusion It is suggest that Tortoises shell have efficacious for treatment of PD.
【Fund】: 国家自然科学基金项目 (No .3 0 2 71677、3 0 3 7183 7);; 广东省自然科学基金项目 (No .3 14 83 )
【CateGory Index】: R742.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 5 Hits
1 Xu Ying,Tang Suoqin,Wang Jing,et al.Department of Pediatrics,General Hospital of PLA,Beijing 100853,China;Neuroprotective effects of honokiol on mouse model with Parkinson's disease[J];Medical Journal of Chinese People's Liberation Army;2008-08
2 Deng Rudong,Li Yiwei,Chen Dongfeng,Li Hui,Zhang Saixia,Zhao Dan,Meng Lingjie,Zhou Jianhong,Meng Dongxue,Zhang Rui,Zhang Hailing(Department of Anatomy,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006);Protective effect of Plastrum Testudinis on the apoptosis of dopamine neurons of rats with Parkinson's disease[J];Chinese Journal of Neuroanatomy;2008-03
3 Zhao Dan1,Chen Dongfeng2,3,Li Yiwei2,Li Hui2,Meng Lingjie2,Zhou Jianhong2,Deng Rudong2,Zhang Rui2(1Department of Anatomy,Hainan College of Medicine,Haikou 571101;2 Department of Anatomy,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006;3State Key Laboratory of Pharmaceutical Biotechnology;Nanjing University;Nanjing 210093);Effects of plastrum testudinis on the expression of bone morphogenetic protein-4 in rat model of Parkinson's disease[J];Chinese Journal of Neuroanatomy;2009-06
4 XIE Xueming,ZHONG Yuansheng,HUANG Chunhua(College of Chinese Materia Medica,Guangzhou University of Traditional Chinese Medicine,Guangzhou510006,China) LI Xican(Dept.of Chemistry,College of Chinese Materia Medica,Guangzhou University of Traditional Chinese Medicine,Guangzhou510006,China) DU Shaohui(Dept.of Internal Medicine,Shenzhen Municipal Hospital of Traditional Chinese Medicine,Shenzhen 518033,China) LI Yiwei,CHEN Dongfeng(Dept.of Anatomy,College of Preclinical Medicine,Guangzhou University of Traditional Chinese Medicine,Guangzhou510405,China);Study of Antioxidant Activities of Plastrum Testudinis in Vitro[J];China Pharmacy;2006-18
5 ZHAO Guo-hua,MENG Qing-gang,YU Xiang-dong,et al Xuanwu Hospital of Capital Medical University,Beijing(100053);A Multi-centered Randomized Double-blinded Controlled Clinical Study on Efficacy of Guiling Pa'an Capsule in Treating Parkinson's Disease[J];Chinese Journal of Integrated Traditional and Western Medicine;2009-07
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Chen Dongfeng, Li Yiwei, Du Shaohui. Department of Anatomy, Guangzhou University of TCM, Guangzhou 510405 China;Effect of tortoses shell on expression of BMP4 in spinal cord following injuried spinal cord[J];Anatomy Research;2003-03
2 CHEN Dongfeng 1, DU Shaohui 2, LI Yiwei 1, ZHANG Jin 1, LI Hui 1 (1.Dept.of Anatomy,Guangzhou University of TCM,Guangzhou 510405,China; 2.Shenzhen Hospital of TCM,Shenzhen 518033,China);Effect of Plastrum Testudinis on Neural Stem Cell After Focal Cerebral Ischemia[J];Journal of Guangzhou University of Traditional Chinese Medicine;2001-04
3 CHEN Dongfeng1,DU Shaohui2,LI Yiwei1,ZHANG Jin1,LI Hui1(1.Department of Anatomy, Guangzhou University of TCM, Guangzhou 510405; 2.Shenzhen Hospital of TCM,Guangdong Shenzhen 518033);Effect of Plastrum Testudinis on Three Subtypes of NOS Expression in Rats with Focal Cerebral Ischemia[J];Traditional Chinese Drug Research & Clinical Pharmacology;2002-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Yue-hua et al (Guangzhou City Polytechnic,Guangzhou,Guangdong 510405);Research and Application of GC-MS Stem Cell Activity Fingerprint of Methyl-esterified Tortoise Shell Extract[J];Journal of Anhui Agricultural Sciences;2008-01
2 Zhang Yue-Hua1,2,Zeng He-Ping1,Chen Dong-Feng3 1(Institute of the Functional Molecule,Department of Chemistry,South China University of Technology,Guangzhou 510641) 2(Guangzhou City Polytechnic,Guangzhou 510405) 3(Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405);Effect of Fatty Acids Methyl Ester from Plastrum Testudinis on Proliferation of Rat Bone Mesenchymal Stem Cell[J];Chinese Journal of Analytical Chemistry;2007-10
3 CHAI Li-juan,WANG Shao-xia,GUO Hong,ZHUANG Peng-wei,GAO Xiu-mei(Pharmaceutical college of Tianjing University of Chinese Medicine,Tianjing 300193,China);Differentiation regulation of neural stem cell and the affection of the Chinese traditional medicine on it[J];Strait Pharmaceutical Journal;2008-10
4 WANG Chun-yan,ZENG He-ping,CHEN Wei(School of Chemistry & Environment,South China Normal University Guangzhou 510631,China);EFFECTS ON PROLIFERATION OF RAT MESENCHYMAL STEM CELL AND CHEMICAL COMPONENTS FROM PLASTRUM TESTUDINIS OBTAINED BY GC-MS[J];Journal of South China Normal University(Natural Science Edition);2007-01
5 ao Jianfeng,Li Jiansheng Geroatrics Research Laboratory, Henan College of Traditional Chinese Medicine;The Present Situation in Studies on Interfering Inflammatory Cascade Peaction Caused by Cerebral Ischemia[J];Journal of Henan College of Traditional Chinese Medicine;2005-02
6 WANG Li-xin,CAI Ye-feng,SUN Jing-bo(Center of Cerebral Vessel Diseases,Guangdong Provincial TCM Hospital,Guangzhou,Guangdong,510120,China);TCM Insight of Proliferation and Differentiation of Endogenous Neural Stem Cells after Cerebral Ischemia[J];Journal of Nanjing University of Traditional Chinese Medicine;2008-04
7 CHEN Dongfeng, DU Shaohui, LI Yhuei, LI Hui ( Dept. of Anatomy, Guangzhou University of TCM, Guangzhou 510405, China; Dept. of Internal Medicine, Shenzhen Hospital of TCM, Shenzhen, China);In-Vitro Induction of Mesenchymal Stem Cells Differentiation intoNeurons in Adult Rats by Serum ContainingCarapax et Plastrum Testudinis[J];Journal of Guangzhou University of Traditional Chinese Medicine;2003-03
8 LU Yu Shanghai Hospital of Traditional Chinese Medicine;Clinical Study on Parkinson's Disease Treated with "Xifeng Zhichan Decoction" and Madopar[J];Shanghai Journal of Traditional Chinese Medicine;2009-06
9 Chen Dongfeng1, Li Hui1, Du Shaohui2, Zhou Jianhong1, Li Yiwei1, Zhang Liqun1, Deng Rudong1, Zhang Saixia1 (1Department of Anatomy, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405; 2Department of Internal Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Shenzhen 518000);EFFECTS OF PLASTRUM TESTUDINIS ON DIFFERENTLATION OF TRANSPLANTED MESENCHYMAL STEM CELLS INTO NEURONS IN THE INJURED SPINAL CORD OF RAT[J];Chinese Journal of Neuroanatomy;2006-02
10 Deng Rudong,Li Yiwei,Chen Dongfeng,Li Hui,Zhang Saixia,Zhao Dan,Meng Lingjie,Zhou Jianhong,Meng Dongxue,Zhang Rui,Zhang Hailing(Department of Anatomy,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006);Protective effect of Plastrum Testudinis on the apoptosis of dopamine neurons of rats with Parkinson's disease[J];Chinese Journal of Neuroanatomy;2008-03
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Chen Yongbo Rao Bin Xin Lan (The Southern Reseach Centre of Potato in Enshi, Hubei,China,445000) (Chinese Japanese Joint Venture Hubei FengJiang Amino Acid CO.LTD.,445800);Rapid Determination of Amino Acid Contents in 9R-Composite Amino Acid Injection Liquid and 3H-Branch Chain Amino Acid Injection Liquid by a Modified AccQ.Tag Method[J];AMINO ACIDS & BIOTIC RESOURCES;2000-02
2 CHEN Li, WU Wei, ZHENG You-liang(Agronomy College,Sichuan Agricultural University,Yaan 625014,China);HPLC Analysis on Dissociative Amino Acids of Houttuynia[J];Amino Acids & Biotic Resources;2004-01
3 Li Rui ping Teachers' College, Hubei Three Gorges University, Yichang 443000 Jiang Shou gui Zhao Jin Environmemtal Institute, Hebei University, BaoDing 071002;Optimization of Amino Acids Analysis Using Precolumn Phenyl Isothiocyanate Derivatization and Reversed phase HPLC[J];AMINO ACIDS & BIOTIC RESOURCES;1998-03
4 LIU Huiling, WANG Dong, ZAHNG Jingang. Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850;The Progress of Collagen in Clinical Medicine[J];Beijing Biomedical Engineering;2005-03
5 PU Xiao Ping 1, LI Xiao Rong 1, LI Hui Nong 1, TU Peng Fei 2, SONG Zhi Hong 2, LI Chang Ling 1 (1. Department of Molecular and Cellular Pharmacology, 2. Department of Natural Medicines, Peking University School of Pharmaceutical Sciences, B;Campneoside Ⅱ of Cistanche tubulosa (Schenk) R. Wight protects neurons from apoptosis induced by neurotoxin 1 methyl 4 phenylpyridinium (MPP +)[J];Journal of Beijing Medical University;2001-03
6 WANG Xue Mei △, FU Hong, LIU Geng Xin (Institute of Integrated of Traditional Chinese and Western Medicine, Peking University, Beijing 100034,China);Effect of Herba Epimedii and Fructus Lycii on mitochondrial DNA deletion, activity of respiratory chain enzyme complexes and ATP synthesis in aged rats[J];Journal of Beijing Medical University;2002-01
7 TIAN Zeng Min *, LIU Shuang, LI Shi Yue,ZHAO Quan Jun,YIN Feng, HAO Qiu Xing,ZHOU Ying (Institute of Neurosurgery, General Hospital of Navy, Beijing 100037, China);Clinical transplantation of human neural stem cells in treatment of Parkinson disease[J];Academic Journal of Second Military Medical University;2003-09
8 FAN Xiao tang, CAI Wen qin, XU Hai wei, YANG Zhong, ZHANG Jin hai (Department of Neurobiology, Third Military Medical University, Chongqing 400038, China);Expressions of noggin mRNA and BMP4 mRNA in rat frontal cortex and hippocampus during different developmental stages[J];Acta Academiae Medicinae Militaris Tertiae;2003-16
9 Wei Dehui, et al ( Department of Pharmacology );Effects of Ophiopogon (Maidong) injection on the blood pressure and left ventricular functions in rats in hemorrhagic shock[J];Journal of First Military Medical University;1989-01
10 Han Ju *, Wei Fuxiang (College of Environmental Science and Engineering, Hebei University of Science and Technology, Shijiazhuang 050018) Yun Zihou (Department of Chemistry, Beijing Normal University, Beijing 100875);Extraction of Lipids with a Low Toxicity Solvent[J];Chinese Journal of Analytieal Chemistry;2002-04
【Secondary References】
Chinese Journal Full-text Database 8 Hits
1 ;龟甲"滋阴补肾"药效相关研究概况[J];Contemporary Medicine;2009-10
2 Deng Rudong,Li Yiwei,Chen Dongfeng,Li Hui,Zhang Saixia,Zhao Dan,Meng Lingjie,Zhou Jianhong,Meng Dongxue,Zhang Rui,Zhang Hailing(Department of Anatomy,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006);Protective effect of Plastrum Testudinis on the apoptosis of dopamine neurons of rats with Parkinson's disease[J];Chinese Journal of Neuroanatomy;2008-03
3 YIN Xiao-ping1,LIN Guan-yu1, BAO Li2,YAO Xin-sheng1,2, KURIHARA Hiroshi1,(1.Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China; 2.College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China) ';Improving Effects of Zhenggaofang-Guilinggao on Oxidative Stress Status[J];Food Science;2009-05
4 Yi Xianghua1,Wu Jing1,Hou Qiuke1,Deng Rudong1,Zhang Saixia1,Li Yiwei1,Chen Dongfeng1,2,Li Hui1,Zhou Jianhong1,Meng Dongxue1,Zhang Hailing1(1Department of Anatomy,Preclinical Medical College,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006;2State Key Laboratory of Pharmaceutical Biotechnology,Department of Biochemistry,Nanjing University,Nanjing 210093);Plastrum Testudinis facilitates the expression of BMP signaling molecules in substantia nigra of PD rats[J];Chinese Journal of Neuroanatomy;2009-05
5 Zhao Dan1,Chen Dongfeng2,3,Li Yiwei2,Li Hui2,Meng Lingjie2,Zhou Jianhong2,Deng Rudong2,Zhang Rui2(1Department of Anatomy,Hainan College of Medicine,Haikou 571101;2 Department of Anatomy,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006;3State Key Laboratory of Pharmaceutical Biotechnology;Nanjing University;Nanjing 210093);Effects of plastrum testudinis on the expression of bone morphogenetic protein-4 in rat model of Parkinson's disease[J];Chinese Journal of Neuroanatomy;2009-06
6 LI Xican,HUANG Kunwang,LAI Bingyi,LAI Wenming(College of Chinese Materia Medica,Guangzhou University of TCM,Guangzhou 510405,China)FENG Aifen(Guangdong Everywhere Dynamical Chemical Co. Ltd.,510730,China)CHEN Dongfeng(College of Basic Medicine,Guangzhou University of TCM,Guangzhou 510405,China);Improvement in Soxhlet Extraction with Ore and Shell Hard Chinese Materia Medica[J];China Pharmacy;2007-30
7 WU Cai-xia,LIU Yu-xin,CHANG Xing,KANG Wen-yi(Institute of Natural Products,Henan University,Kaifeng 475004,China)WU Cai-xia,KANG Wen-yi(Henan Center for Disease Control and Prevention,Zhengzhou 450003,China);In Vitro Antioxidant Activity of Extracts from Polygonum alatum[J];China Pharmacy;2009-24
8 LI Qing-hua(Jilin Medical College,Jilin 132013,China)WEI Chun-yan(Jilin Academy of Agricultural Sciences,Changchun 130033,China)HUANG Jiu-lin,LI Jian-dong(Key Laboratory for Vegetation Ecology of Ministry of Education,Northeast Normal University,Changchun 130024,China);Determination of Total Flavonoids and Quercetrin in Different Parts of Apocynum venetum from Songnen Grassland & Its Antioxidant Activity[J];China Pharmacy;2009-33
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 CHEN Dongfeng 1, DU Shaohui 2, LI Yiwei 1, ZHANG Jin 1, LI Hui 1 (1.Dept.of Anatomy,Guangzhou University of TCM,Guangzhou 510405,China; 2.Shenzhen Hospital of TCM,Shenzhen 518033,China);Effect of Plastrum Testudinis on Neural Stem Cell After Focal Cerebral Ischemia[J];Journal of Guangzhou University of Traditional Chinese Medicine;2001-04
2 BIANWEI, YANGJING, TANGKE, JINGNAI HE  (Shanghai Institute of Biochemistry, Chinese Academy of Science; Shanghai Research Center of Life Sciences, Shanghai 200031);NESTIN EXPRESSION DURING P19 NEURON DIFFERNTIATION *[J];ACTA PHYSIOLOGICA SINICA;1999-03
3 DENG Qiang; XU Hong; ZHU Dong-Ya;(New Drug Research Center, China Pharmaceutical University, Nanjing 210009);Relationship between iNOS and the late-phase cerebral ischemia[J];CHINESE BULLETIN OF LIFE SCIENCES;1999-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved