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《Anatomy Research》 2008-05
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Experimental research on the sedative and hypnotic effect of Rhodiola rosea

CHEN Qiao-ge,ZENG Yuan-shan,TIANG Jiu-yu,QIN Ya-jing,CHEN Sui-jun,ZHONG Zhi-qiang.Division of Neurosciences,Department of Histology and Embryology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080 China  
Objective To explore the sedative and hypnotic effect of Chinese Medicinal plant Rhodiola rosea.Methods Thirty male SD rats were divided into six groups including normal control group(no-drench any medicine),negative control group(drench sodium carboxymethy cellulose),diazepam group(drench diazepam carboxymethy cellulose),low dose Rhodiola rosea group(drench low dose Rhodiola rosea carboxymethy cellulose)、 medium dose Rhodiola rosea group(drench medium dose Rhodiola rosea carboxymethy cellulose)and high dose Rhodiola rosea group(drench high dose Rhodiola rosea carboxymethy cellulose).1 hour after 0.1% pentobarbital intraperitoneal injection,the sleep latency and the sleeping time of rats were recorded.Namely,time elapsed between the administration of pentobarbital until loss of righting reflex was recorded as the sleep latency,while the time from the loss to its recovery was considered as the sleeping time.To observe the effect of different dose Rhodiola rosea on sleep latency and sleeping time.Results Compared with normal control group(3.24± 0.22;93.96±2.25),intragastric administration middle dose Rhodiola rosea and high dose Rhodiola rosea can shorten rat's sleep latency(2.42±0.33,P0.01;2.16±0.13,P0.01)and prolong rat's sleeping time(102.54±3.15,P0.05;107.10±7.75,P0.05).Conclusion The middle dose Rhodiola rosea and high dorsage Rhodiola rosea may have the sedative and hypnotic effects.
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 2 Hits
1 TENG Bao-xia~(1,2),LIU Nai-fa~1(1.Department of Biology,Lanzhou University,Lanzhou 730000,China;2.Gansu Provincial Institute for Drug Control,Lanzhou 730000,China);Effects of Jingfeng capsule on anti-hypoxia capacity in mice[J];West China Journal of Pharmaceutical Sciences;2006-04
2 LI Yu-shan(College of Information & Engineering,Sichuan Agriculture University, Ya′an 625014, China);Advances in Comprehensive Studies on Rhodiola Plants[J];Chemistry and Industry of Forest Products;2009-02
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