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《Journal of Hepatobiliary Surgery》 2004-03
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PROTECTIVE EFFECT OF N-ACETYLCYSTEINE ON HEPATIC DAMAGE INDUCED BY INTESTINAL ISCHEMIA REPERFUSION IN RATS

Liu Wei ming,Gu Zhi cheng,Affiliated Children Hospital,College of Medical,Suzhou Universi ty,Suzhou215003 China)  
Objective To investigate protective effects of n acetylcysteine and expression onP selectin mRNA and pro tein on hepatic tissue during intestinal ischemia reperfusion.Methods The mRNA transcription and protein translation levels of P selectinwere assayed with nRT PCR and immunohistochemistry in an ischemia reperfusion rat model.Blood,gut,hepatic myeloperoxidase(MPO)activity and plasma alanine aminptransferase(ALT)were determined as well.Results The highest P selectin mRNA expression was found on the group of 1h post ischemia reperfusion and its protein expressionwere lower or not.ALT activity markedly increased as early as0.5h after reperfusion following decreased,and reached a peak at the 4h after reperfusion(271.00±29.89 u/l, P0.01 ),then decreased obviously after treatment with n acetylcysteine at reperfu sion.MPO activity reached a peak at the 0.5h after reperfusion(148.83±22.80 u/l, P0.01 )and decreased obviously after treatment with n acetylcysteine at reperfusion as well.Conlusion NAC could inbhibit both P selectin expression and de creased the activation of PMN in intestinal and hepatic tissue,and avoid hepatic damage induced by intestinal ischemia reperfu sion.
【CateGory Index】: R574
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