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《Journal of Hepatobiliary Surgery》 2005-05
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THE SIGNIFICANCE OF BLOOD AFPmRNA CHANGE IN HEPATOCELLULAR CARCINOMA PATIENTS TREATED WITH RADIOFREQUECY ABLATION

(Du xi-lin,Ma Qingjiu Lu Jian-guo,et al.Department of General Surgery of Tang Du Hospital.Fourth Military Medical University Xi'an 710038,China)  
Objective To study the significance of blood AFPmRNA in hepatocellular carcinoma(HCC) patients treated with radiofrequency ablation.Methods Using nested RT-PCR,AFPmRNA content in 119 blood sample from the hepatocellular carcinoma patients were determined and the changes observed before radio-frequency ablation*RFA),48h,72h,1 week and 2 week after RFA.Result In 183 patients with blood AFPmRNA being negative before RFA,positive AFPmRNA was found in 62 cases 72h after RFA and disappeared two week after RFA;129patients with blood AFPmRNA being positive before RFA,negative AFPmRNA was found in 112 cases two week after RFA;17 cases was positive two week after RFA.Conclusion RFA lead to change of AFPmRNA in blood;AFPmRNA was used as a marker of HCC remain and recurrence after RFA.
【Fund】: 陕西省自然科学研究项目(2002C202)
【CateGory Index】: R735.7;
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1 (Du xi-lin,Ma Qingjiu Lu Jian-guo,et al.Department of General Surgery of Tang Du Hospital.Fourth Military Medical University Xi'an 710038,China);THE SIGNIFICANCE OF BLOOD AFPmRNA CHANGE IN HEPATOCELLULAR CARCINOMA PATIENTS TREATED WITH RADIOFREQUECY ABLATION[J];肝胆外科杂志;2005-05
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