A New Method foir the Synthesis of 5(4H)-Oxazolones from N-Acyl-a-Amiho Acids
Huang Huamin, Zhang Jianing, Wang Jingyang (Department of Chemistry, Jilin University, Changchun)
In K2CO3-CH3COCH3-H2O system, N-acyl-a-amino acids ( Ⅰ a-j) were prepared by the reaction of amino acids with N-acyl thiazolidines-2-thiones and the yields were 76%-95%. The synthesis of saturated 5(4H)-oxazolones( Ⅱa-h) from I under mild reaction conditions in yields of 43% - 84% by the use of cyanuric chloride as a condensing reagent in the presence of triethylamine was reported. Unsaturated 5(4H)-oxazolones (Ⅲa-1) were obtained from I in the yields of 43%-93% by the aldol reaction in which Fe2SO4)3 was used as a catalyst.
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