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Studies on D-Galactose-containing DTPA Bisamide Gadolinium Complexes as Liver-targeting MRI Contrast Agents

FU Yan-Jun; ZHUO Ren-Xi(Department of Chemistry, Laboratory of Biomedical Polymer Materials of the State EducationCommission of China, Wuhan University, Wuhan, 430072)  
New lactose-or D-galactose-containing diethylenetriaminepentaacetic acidbisamide ligands and their gadolinium complexes were synthesized by the reaction of bis(N-hydroxysuccinimide ester)of diethylenetriaminepentaacetic acid with amino-containing lac-tose or D-galactose derivatives. Chemical structures of ligands and Gd complexes were char-acterized. In vitro spin-lattice relaxivity and acute toxicity in mice of the complexes havebeen preliminarily investigated. Magnetic Resonance lmaging for rabbit shows that the con-trast agent bearing galactose could be targeted to the liver.
【Fund】: 国家教育委员会博士点基金
【CateGory Index】: O627
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