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《CHEMICAL RESEARCH IN CHINESE UNIVERSITIES》 1997-07
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Studies on D-Galactose-containing DTPA Bisamide Gadolinium Complexes as Liver-targeting MRI Contrast Agents

FU Yan-Jun; ZHUO Ren-Xi(Department of Chemistry, Laboratory of Biomedical Polymer Materials of the State EducationCommission of China, Wuhan University, Wuhan, 430072)  
New lactose-or D-galactose-containing diethylenetriaminepentaacetic acidbisamide ligands and their gadolinium complexes were synthesized by the reaction of bis(N-hydroxysuccinimide ester)of diethylenetriaminepentaacetic acid with amino-containing lac-tose or D-galactose derivatives. Chemical structures of ligands and Gd complexes were char-acterized. In vitro spin-lattice relaxivity and acute toxicity in mice of the complexes havebeen preliminarily investigated. Magnetic Resonance lmaging for rabbit shows that the con-trast agent bearing galactose could be targeted to the liver.
【Fund】: 国家教育委员会博士点基金
【CateGory Index】: O627
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1 WANG Jun-Wei~1,SHI Jian-Guo~1,WANG Jing~2,SHU Bo-Xue~3,LIU Yan-Fang~1~1Department of Pathology,School of Basic Medicine,~2Department of Nuclear Medicine,Xijing Hospital,Fourth Military Medical(University),Xi'an 710033,China,~3Department of Nuclear Medicine,Xi'an Gaoxin Hospital,Xi'an 710075,China;Radiolabeling of 2 kinds of single chain antibodies of anti-hepatocellular carcinoma with ~(99m)Tc[J];Journal of the Fourth Military Medical University;2006-15
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【Secondary References】
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1 JIA Wei-guo (College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China);THE AFFECT OF LIGAND SHAPE TO RARE EARTH METAL Gd~Ⅲ COMPLEXES WITH AMINOCARBOXYLIC ACIDS ON COORDINATION STRUCTURES AND COORDINATION NUMBERS[J];Journal of Anhui Normal University(Natural Science);2004-04
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