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Embedment and Deliverance of 5 Fluorouracil from Blended Membrane of Silk Fibroin and 5 Fluorouracil

CHEN Jian Yong , LIU Guan Feng, SHEN Zhi Quan\+ (College of Textile Technology, Zhejiang Silk Institute of Technology, Hangzhou 310033, China; Department of Polymer Science and Engineering, Zhejiang University\+, Hangzhou 310027, China)  
The silk fibroin membrane is an amphoteric ion exchange membrane composed of both weak acidic and weak basic groups. 5 Fluorouracil is an anti cancer drug. The condition of 5 fluorouracil blended into silk fibroin membrane has been investigated, then deliverance of 5 fluorouracil from blended membrane of silk fibroin and 5 fluorouracil was measured in the pH range from 3 to 9. The results of SEM, FTIR, DSC show that 5 fluorouracil could be evenly blended into silk fibroin protein. After coating with silk fibroin, the dissolve rate of 5 fluorouracil fixed on silk fibroin and 5 fluorouracil blended membrane could be descended, and the delivery time of 5 fluorouracil could be prolonged. The delivery time and dissolve rate also depends on pH values of soaking solution. It is expected that silk fibroin membrane could be used as the matrix of 5 fluorouracil delivery system.
【Fund】: 浙江省跨世纪学术和技术带头人培养基金
【CateGory Index】: R944.9
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