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《CHEMICAL RESEARCH IN CHINESE UNIVERSITIES》 2000-06
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Synthesis and Antitumor Activities of Spin Labeled Derivatives of Daunorubicin and Doxorubicin

MA Cheng, WANG Yan Guang , CHEN Yao Zu [WT5”BX](Department of Chemistry, Zhejiang University, Hangzhou 310027, China) [WT5HZ]  
Five new spin labeled derivatives of daunorubicin and doxorubicin(5_9) were synthesized and their structures were identified by IR, MS and ESR as well as elementary analysis. All new compounds were evaluated for their antitumor activities against mouse leukemia P388, B16, human stomach carcinoma SGC 7901 and human liver cancer SMMC 7721 cells in vitro. The preliminary results showed that compound 9 was as active as the clinically used doxorubicin. [WT5HZ]
【Fund】: 国家自然科学基金 !(批准号 :2 9972 0 3 7)
【CateGory Index】: TQ465
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【Citations】
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1 HE Feng1, LIU Zong- chao2*, LUO Yi- fan1, CHENG Zhi- yi1, ZHU Xiao- feng2, LI Zhi- ming2, XIE Bing- feng2, FENG Gong- kan2 1. Department of Chemistry, Department of Natural Drug, Sun Yat- sen University of Medical Sciences, Guangzhou 510089;QSAR Study of Podophyllotoxin Derivatives as Potential Antitumor Drugs[J];Chinese Journal of Cancer;2001-04
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