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Synthesis and Antitumor Activities of Spin Labeled Derivatives of Daunorubicin and Doxorubicin

MA Cheng, WANG Yan Guang , CHEN Yao Zu [WT5”BX](Department of Chemistry, Zhejiang University, Hangzhou 310027, China) [WT5HZ]  
Five new spin labeled derivatives of daunorubicin and doxorubicin(5_9) were synthesized and their structures were identified by IR, MS and ESR as well as elementary analysis. All new compounds were evaluated for their antitumor activities against mouse leukemia P388, B16, human stomach carcinoma SGC 7901 and human liver cancer SMMC 7721 cells in vitro. The preliminary results showed that compound 9 was as active as the clinically used doxorubicin. [WT5HZ]
【Fund】: 国家自然科学基金 !(批准号 :2 9972 0 3 7)
【CateGory Index】: TQ465
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