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《Chemical Research In Chinese Universities》 2001-05
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Studies on the Binding Nature in Molecularly Imprinted Polymer Selective for 4-Aminopyridine

GUO Hong Sheng 1, HE Xi Wen 1,* , JING Ying 2, LIANG Hong 2 (1. Department of Chemistry, Nankai University, Tianjin 300071, China; 2. College of Biology and Chemistry, Guangxi Normal University, Guilin 541004, China)  
A molecularly imprinted polymer was prepared using 4 aminopyridine as template. The bulk polymer obtained was ground up, sieved and investigated in equilibrium binding experiments to evaluate the binding characteristics of the 4 aminopyridine imprinted polymer. Scatchard analysis showed that two classes of binding sites were produced in the polymer matrix and their dissociation constants were calculated to be 6.0 μmol/L and 1.2 mmol/L respectively, by utilizing the model of multiple independent classes of binding sites. The substrate selectivity of the polymer was investigated. The results showed that the imprinted polymer exhibited much higher affinity for 4 aminopyridine among the tested compounds. \{ 1H NMR\} studies and the analysis of the resonance structure of 4 aminopyridine indicated that the selective binding interaction between the template and binding sites in the polymer arose from their ionic interaction.
【Fund】: 国家自然科学基金! (批准号 :2 9775 0 11);; 天津市自然科学基金! (批准号 :0 0 3 60 2 2 11);; 广西壮族自治区教育厅科研项目资助课题
【CateGory Index】: O633
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