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《Chemical Research In Chinese Universities》 2001-05
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Electrochemical Studies of Mitoxantrone Interaction with DNA at a Ni/GC Ion Implantation Modified Electrode

HU Jin Bo, SHANG Jun, LI Qi Long * (Department of Chemistry, Beijing Normal University, Beijing 100875, China)  
The electrochemical behavior of mitoxantrone interaction with DNA at a Ni/GC modified electrode was studied by linear sweep and cyclic voltammetry. In 0.05 mol/L Tris 0.5mol/L NaCl solution (pH=7.1), the reaction of DNA with MX formed an electrochemically nonactive complex, resulting in a decrease in the MX equilibrium concentration and its reduction current. The composition of the complex was n (MX)∶ n (DNA)=2∶1. The combining constant was 1.61×10 12 . The electrode reaction rate constant k 0 and the electron transfer coefficient α were 0.33 s -1 and 0.41, respectively. The decrease in peak current was proportional to DNA concentration and can be used to determine DNA concentration.
【Fund】: 国家自然科学基金! (批准号 :2 9875 0 0 3 );; 教育部博士学科点基金! (批准号 :980 0 2 70 9)资助
【CateGory Index】: O646
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