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《Chemical Research In Chinese Universities》 2001-05
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Characterization of the Adsorption of Bovine Serum Albumin on Hydroxylapatite

YIN Gang, ZHAN Jin, LIU Zheng *, YUAN Nai Ju (Department of Chemical Engineering, Tsinghua University, Beijing 100084, China)  
Experimental studies on the effects of the concentration of PO 3- 4 and Ca 2+ , ion strength and pH of buffer on the polarity and magnitude of ζ potential of hydroxylapatite(HAP) were carried out in present study to characterize the surface physicochemical properties of hydroxylapatite. Adsorption of bovine serum albumin(BSA) on HAP was carried at different conditions in terms of pH, ionic strength, and the concentration of PO 3- 4 to establish the knowledge of adsorption mechanism. A Langmuir adsorption isotherm was obtained and the apparent activation energy and adsorption heat were interpreted. The low magnitude of the apparent activation energy and the adsorption heat indicated the fast adsorption of BSA on hydroxylapatite was a physical adsorption in nature.
【Fund】: 国家自然科学基金! (批准号 :2 96760 2 2 );; 北京市自然科学基金! (批准号 :2 992 0 16)资助
【CateGory Index】: O647.3
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