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《Chemical Research In Chinese Universities》 2001-12
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Studies on Synthesis and Anticancer Activity of Thiosemicarbazones

HU Wei Xiao *, SUN Nan, YANG Zhong Yu (Institute of Pharmaceutical Engineering, Zhejiang University of Technology, Hangzhou 310014, China)  
Sixteen of thiosemicarbazone(Ⅰ) was synthesized. Hydrazine reacts with carbondisulfide and dimethyl sulfate in the presence of potassium hydroxide to form compound Ⅱ with yield 60%. compound Ⅱ reacts with ketone or aldehyde to form compound Ⅲ. Compound Ⅲ reacts with \{ N substituted\} piperazine to form Ⅰ with yield 27%_85%. The structures of the compounds were comfirmed by IR, NMR, elemental analysis, and the results shows that the thiosemicarbazone with proper substituents has somewhat activity. These compounds are valuable ones for being studied further.
【Fund】: 浙江省自然科学基金 (批准号 :2 0 0 0 16 )资助
【CateGory Index】: O626
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