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《Chemical Research In Chinese Universities》 2002-01
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Studies on the Synthesis, Relaxivity and Liver-targeting of DTPA-Pyridoxol Ester Gadolinium Complexes

DING Xiong Jun, ZHUO Ren Xi *, FU Gong Cheng (Key Laboratory of Biomedical Polymer Materials, Ministry of Education; Department of Chemistry, Wuhan University, Wuhan 430072, China) \{  
Several\} new DTPA pyridoxol ester ligands were synthesized by reacting diethylene\|triaminepentaacetic anhydride(DTPAA) with pyridoxol derivatives. Their gadolinium complexes were also prepared. Their T 1 relaxivities in water were measured. The 99 Tc labelled combination radioactivity experiment with liver cells and kidney cells of mice showed that ligands 2 and 6 possessed an excellent liver targeting property. The results of animal MR imaging experiment further confirmed that the signals in liver were obviously strengthened after injection of Gd2 and Gd6.
【Fund】: 国家自然科学基金 (批准号 :2 98740 2 8)资助
【CateGory Index】: O641.4
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