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《Chemical Research In Chinese Universities》 2003-01
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Studies on the Synthesis and RNA Binding of Ruthenium (Ⅱ) Polypyridine Complexes

XU Hong 1,2, DENG Hong 1, HU Hong-Yu 3, LIU Jian-Zhong 1, CHAO Hui 1, LIU Jie 1, JI Liang-Nian 1* (1. School of Chemistry and Chemical Enginering, Zhongshan University, Guangzhou 510275, China; 2. Normal College of Shenzhen University, Shenzhen 518060, China; 3. Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China)  
A new ruthenium polypyridine complex, [Ru(phen) 2(pMIP)] 2+(phen=1,10-phenanthroline, pMIP=2-(4-methylphenyl)imidazo phenanthroline), was synthesized and characterized by elementary analysis, MS and 1H NMR. Spectroscopic methods have been carried out on the interaction mechanism of the Ru (Ⅱ) complex with yeast tRNA systematically. The experimental results indicate that the complex binds to yeast tRNA with an intercalative mode possibly, and interacts with yeast tRNA enantioselectively. The experimental results also suggest that spectroscopic method is effective on studying the interaction mechanism of Ru (Ⅱ) complexes with RNA. Information obtained from the study is potentially useful in the design of new RNA-targeting drugs.
【Fund】: 国家自然科学基金 (批准号 :30 0 70 188);; 广东省自然科学基金 (批准号 :0 112 17)资助
【CateGory Index】: O641.4
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