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《Chemical Research In Chinese Universities》 2003-07
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Preparation of Molecularly Imprinted Microspheres Against Acidic Indometacin and Its Chromatographic Characterization by Aqueous Micro-suspension Polymerization

LAI Jia-Ping, LU Chun-Yang, HE Xi-Wen * (State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Department of Chemistry, Nankai University, Tianjin 300071, China)  
The molecularly imprinted microspheres(MIMs) for high performance liquid chromatography were synthesized by aqueous micro-suspension polymerization. The acidic indometacin, one of the antidepressants, was used as the template and basic 4-vinylpyridine was used as functional monomer. The influences of pH of mobile phase on the capacity factor(k′), separation factor(α) and selection factor(β) of indometacin were investigated in detail. All the results showed that the MIMs exhibited specific recognition and affinity to indometacin only in pH4.0 eluent; and the specific recognition of MIMs was lost gradually in pH4.0 eluent. By comparing the retention behavior of indometacin and 4-aminopyridine (4-AP) on the MIMs column, it proved that the recognition of MIMs to indomeatcin synthesized by 4-vinylpyridine as a cross-linker mainly relied on the ion-pair interaction between the nitrogen atom on the pyridine ring and the carboxyl on the indometacin, and the π-π interaction between the pyridine ring and the template molecule. This was just contrary to that MIMs synthesized by methacrylic acid as the cross-linker.
【Fund】: 吸附分离功能高分子材料国家重点实验室开放基金 (南开大学 );; 国家自然科学基金 (批准号 :2 0 175 0 0 9);; 教育部博士学科点基金 (批准号 :2 0 0 2 0 0 5 5 0 0 2 )资助
【CateGory Index】: O657.7
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