Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chemical Research In Chinese Universities》 2003-08
Add to Favorite Get Latest Update

Preliminary Computer Simulation of Spatial Structure of SARS Coronavirus E-protein

CHEN Yan-Tao, LUO Zhong-Lin, DING Jian-Dong * (Department of Macromolecular Science, Key Laboratory of Molecular Engineering of Polymers of Educational Ministry, Fudan University, Shanghai 200433, China)  
The HP coarse-grained model has been applied to study three-dimensional spatial structures of a protein via lattice Monte Carlo simulation, in which residues exhibit different hydropathical energies. Reversed HP model has also been introduced to deal with protein under a lipid environment. The simulation approach seems very efficient. Preliminary computer experiment has been performed to study E-protein which is believed in the envelope of SARS(Severe Acute Respiratory Syndrome) associated coronavirus. Coil-globule transition has been reproduced in E-protein under a completely aqueous or lipid environment. Heterogeneity of this 76-residue polypeptide is verified to be important. Aqueous environment results in a hydrophobic core and hydrophilic loops. In contrast, lipid environment makes central segment as bridge or loop linking two relatively hydrophilic marginal segments.
【Fund】: 国家自然科学基金 (批准号 :2 982 5 10 9 2 0 1740 0 6 );; 高等学校青年教师教学和科研奖励基金;; 国家“九七三”项目 (批准号 :G19990 5 430 6 -0 3);; “八六三”项目 (批准号 :2 0 0 1AA2 15 45 1);; 上海市科技发展基金 (批准号 :0 2 DZ110 10 )资助
【CateGory Index】: R373
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 CHEN Yan-tao and LIU Jian-hong College of Chemistry and Chemical Engineering Shenzhen Key Laboratory of Functional PolymerShenzhen University Shenzhen 518060 P.R.China;Computer simulation of SARS coronavirus-associated E protein's folding in biological membrane[J];Journal of Shenzhen University Science and Engineering;2010-01
Chinese Journal Full-text Database 10 Hits
1 ZHANG Wei CHEN Jin-chun(College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China);Separation and purification of recombinant snake neurotoxins from Pichia pastoris[J];Journal of Beijing University of Chemical Technology;2005-06
2 CHEN Cui-li~1,SHI Ding-ji~2(1.College of Arts and Science of Beijing Union University,Beijing 100083,China;2.China Institute of Botany,The Chinese Academy of Science, Beijing 100093,China);Construction of Anabaena Transferred the Gene Encoding the Human Granulocyte Colony-stimulating Factor[J];Journal of Beijing Union University;2005-03
3 ZHAO Jing~(*1,2),TANG Huan-wen~1,ZHU Xun-zhi~1(1.Dept.of Appl.Math.,Dalian Univ.of Technol.,Dalian 116024,China;2.Dept.of Math.and Phys.Sci.,Shandong Inst.of Light Ind.,Jinan 250100,China);An improvement of simulated annealing algorithm and study of its application[J];Journal of Dalian University of Technology;2006-05
4 PENG Yan,WANG Yong,SONG Fang-Zhou,WANG Ya-PingKey Laboratory of Biochemistry and Molecular Pharmacology,Chongqing University of Medical Sciences,Chongqing 400016,China;Expression and purification of recombinant human IL-18 in pichia pastoris[J];Journal of The Fourth Military Medical University;2005-22
5 CHE Xiao-yan 1 , QIU Li-wen 1 , PAN Yu-xian 1 , XU Hua 1 , HAO Wei 1 , LIAO Zhi-yong 1 , MEI Ya-bo 1 , ZHANG Li-ya 1 , WAN Zhuo-yue 2 , YUAN Guo-yong 3 , HUANG Zhen 41 Central Laboratory, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China; 2 Disease Control and Prevention Center of Guangdong Province, Guangzhou 510300, China; 3 Department of Microbiology, University of Hong Kong, Hong Kong, China; 4 Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China;Rapid and efficient preparation of monoclonal antibodies against SARS-associated coronavirus nucleocapsid protein by immunizing mice[J];Journal of First Military Medical University;2003-07
6 CHEN Zhan-hua~(1),YANG Guang-hui~(*,1,2)(1.Educational College of Jilin Province,Changchun 130020,China; 2.State Key Laboratory of Theoretical and Computational Chemistry,Institute of Theoretical Chemistry,Jilin University,Changchun 130023,China);Study on the three-dimensional structure of rat estrogen sulfotransferase[J];Journal of Molecular Science;2006-05
7 YU Ping (Genetic Engineering Laboratory,Hangzhou University of Commerce,Hangzhou 310035);Advance in Pichia pastoris expression system[J];Industrial Microbiology;2005-03
8 CHEN Yantao~(1,2),DING Jiandong~(2,3)(()~1 Shenzhen Key Laboratory of Functional Polymer,School of Chemistry and Chemical Engineering,Shenzhen University,Shenzhen 518060)(()~2 Key Laboratory of Molecular Engineering of Polymers of Ministry of Education(Fudan University),()~3 Department of Macromolecular Science,Fudan University,Shanghai 200433);DYNAMIC MONTE CARLO SIMULATION OF KINETIC PROCESS FOR POLYMER COLLAPSE TRANSITION[J];Acta Polymerica Sinica;2009-12
9 CHEN Hao(School of Mathematics and Computer Science, Hubei University, Wuhan 430062,China);Protein conformation prediction based on simulated annealing algorithm[J];Journal of Hubei University(Natural Science Edition);2005-02
10 LI, Min-Yonga,b LU, Jing-Fenb XIA, Lin*,a (a Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009) (b National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083);Receptor-based Molecular Modeling Study on Antagonist-Bound Human α_(1A),α_(1B)和α_(1D)-Adrenoceptors[J];Acta Chimica Sinica;2005-20
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved