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《Chemical Research In Chinese Universities》 2004-09
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Synthesis, Relaxivity of Gd(Ⅲ), Fe(Ⅲ) and Mn(Ⅱ) Complexes with Dihydropyridine Derivatives of Diethylenetriaminepentaacetic Acid

ZHENG Shu-Zhan, JIAN Ya-Jun, BAI Yin-Juan, XIE Zhan-Feng, CHANG Jian-Hua* (Department of Chemistry, Northwest University, Xi′an 710069, China)  
Four novel ligands of DTPA-dihydropyridine derivatives which were designed for magnetic resonance imaging contrast agents were synthesized by the reaction between DTPA-dianhydride and 4-aniline-1,4-dihydropyridines. Their complexes of gadolinium, manganese and iron were prepared. Spin-lattice relaxivities(t 1) of the complexes was investigated. The results showed that all the complexes have relaxation effects on the protons in surrounding water molecules. The Gd(Ⅲ) complexes have higher relaxivities than those of Fe(Ⅲ) and Mn(Ⅱ) complexes. The NMR t 1 relaxivities(R 1) of Gd(Ⅲ)DTPA-dihydropyridines complexes are 5.50, 5.58, 5.20 and 5.49 L·mmol -1·s -1, which are higher than that of their parent complex, GdDTPA 2-. That indicating that the Gd(Ⅲ) complex possesses the precondition to be the contrast agents for magnetic resonance imaging.
【Fund】: 陕西省自然科学基金 (批准号 :2 0 0 2 B0 2 )资助
【CateGory Index】: O641.4
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