Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chemical Research In Chinese Universities》 2004-10
Add to Favorite Get Latest Update

Preparation of Chitosan/Hydroxyapatite Nanocomposite with Layered Structure via in-situ Compositing

LI Bao-Qiang, Hu Qiao-Ling *, WANG Mang, SHEN Jia-Cong (Institute of Polymer Composites, Zhejiang University, Hangzhou 310027, China)  
Incorporation of hydroxyapatite(HA) with chitosan(CS) could improve the bioactivity and the bone-bonding ability of CS/HA composite, which maybe sacrifice its mechanical properties. The CS/HA nanocomposite with a high performance was prepared via in-situ compositing route. The key of in-situ compositing is that a pre-precipitated CS membrane was used to obstruct the CS/HA precursor from NaOH aqueous solution. The CS membrane controlled the process of CS precipitation and transformation of HA from the precursor due to changing of pH simultaneously and tardily. XRD were carried out to determine the component of CS/HA composite. TEM and SEM were performed to investigate the morphology of HA granules and CS/HA composite. The results showed that the in-situ formed calcium phosphate in CS was exactly HA, and that nano-size HA granules(30—50 nm width, 100 nm length) were dispersed in CS matrix uniformly. The result of SEM shows that the structure of CS/HA composite prepared by in-situ compositing is layered-by-layered, which can further prove the mechanism of in-situ compositing. The mechanical properties of CS/HA were evaluated by the three point bending test. The bending strength and modulus of CS/HA(mass ratio 100/5) are 86 MPa and 3.4 GPa, which is much higher than that of cancellous bone, 22 MPa. This material is of potential application as bone substituent in hard tissue reparation.
【Fund】: 国家自然科学基金 (批准号 :5 0 173 0 2 3 5 0 3 3 3 0 2 0 );; 浙江省科技计划项目 (批准号 :2 0 0 3 C3 10 44 )资助
【CateGory Index】: R318.08
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 5 Hits
1 LU Xiaoying,WANG Xiuhong,LIU Zhi,WENG Jie(Key Lab of Advanced Technologies of Materials(Ministry of Education),School of Materials Science & Engineering,Southwest Jiaotong University,Chengdu 610031,China);Effect of pH value on the nano-hydroxyapatite/chitosan composites via in-situ hydrothermal precipitation[J];Acta Materiae Compositae Sinica;2009-04
2 WU Fang,DAI Bo-chuan,LI Wei-zu(College of Pharmacy;Fujian Medical University;Fuzhou 350004,China);Preparation and investigation of nano-hydroxyapatite/chitosan-algin composite material[J];Strait Pharmaceutical Journal;2009-03
3 Cao Yang Liu Xiaorong Ru Ling Chen Lei Huang Yiping Shen Yuhua(School of Chemistry and Chemical Engineering,Anhui University,Anhui Hefei 230039);The Pgogress in Prepartion of Nano-hydroxyapatite/Polymer Composite Biomaterials[J];Chemical Industry Times;2007-02
4 He Dan Xu Suhua You Qingqing Zhang Mingxia Xiao Xiufeng Liu Rongfang (College of Chemistry and Materials Science,Fujian Normal Universty,Fujian Fuzhou 350007);Chitosan Template-Induced Biomimetic Synthesis of Nano Spindle-shaped Hydroxyapatite[J];Chemical Industry Times;2007-07
5 Lü Caixia,YAO Zihua(School of Chemistry and Environmental Science,Hebei University,Baoding 071002);Progress of hydroxyapatite/ chitosan composite materials[J];Chemical Industry and Engineering Progress;2006-07
Chinese Journal Full-text Database 2 Hits
1 HU Qiao-Ling *, QIAN Xiu-Zhen, LI Bao-Qiang, SHEN Jia-Cong (Institute of Polymer Composite Material, Zhejiang University, Hangzhou 310027, China);Studies on Chitosan Rods Prepared by in situ Precipitation Method[J];Chemical Research In Chinese Universities;2003-03
2 LI Baoqiang, HU Qiaoling, QIAN Xiuzhen, FANG Zhengping, SHEN Jiacong (Institute of Polymer Composite, Zhejiang University, Hangzhou 310027);BIOABSORBABLE CHITOSAN/HYDROXYAPATITE COMPOSITE ROD PREPARED BY in-situ PRECIPITATION FOR INTERNAL FIXATION OF BONE FRACTURE[J];Acta Polymerica Sinica;2002-06
Chinese Journal Full-text Database 10 Hits
1 CHEN Liang~1,WU Hai-ruo~2,HU Qiao-ling~1,SHEN Jia-cong~1(1 Key laboratory of Macromolecule Synthesis and Functionalization,Ministry of Education,Institute of Polymer Composites,Zhejiang University,Hangzhou 310027,China;2 Zhejiang Technology Institute of Economy,Hangzhou 310012,China);Biomineralization Behavior of Biomimetic Chitosan Rod[J];Journal of Materials Engineering;2006-S1
2 CHEN Fuping HU Qiaoling WU Jia SHEN Jiacong Institute of Polymer Composites, Zhejiang University, Hangzhou 310027;Preparation of superparamagnetic hydroxyapatite/chitosan rod[J];Chinese Journal of Materials Research;2006-03
3 SHEN Bingxing1,2,HU Xiaolan1,2,DONG Yanming1,2 (1.College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China;2.Department of Materials Science and Engineering,College of Materials,Xiamen University,Xiamen 361005,China);Bioabsorbable chitosan rod reinforced by chitosan fiber[J];Acta Materiae Compositae Sinica;2008-06
4 HU Qiao-Ling~*, LEI Yong, ZHANG Zhong-Ming, SHEN Jia-Cong(Institute of Polymer Composite Materials, Zhejiang University, Hangzhou 310027, China);Surface Biomimetic Waterproof Modification of Chitosan Rod[J];Chemical Research In Chinese Universities;2005-06
5 HU Qiao-Ling~*,CHEN Fu-Ping,LI Bao-Qiang,SHEN Jia-Cong (Institute of Polymer Composites,Zhejiang University,Hangzhou 310027,China);Preparation of Orientated Magnetite/Chitosan Nano-composite Material via In-situ Precipitation[J];Chemical Research In Chinese Universities;2005-10
6 HU Qiao-Ling*, CHEN Zhong-Ke, CHEN Liang, SHEN Jia-Cong (Institute of Polymer Composites, Zhejiang University, Hangzhou 310027, China);Preparation of CaCO_3/Chitosan Three-dimentinal Composite Material via in-situ Precipitation[J];Chemical Journal of Chinese Universities;2006-03
7 WANG Hong, HUANG Liang, SUN Yan (Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072);PREPARATION AND CHARACTERIZATION OF THEOPHYLLINE CRYSTAL-IMPRINTED POLYMERS[J];Acta Polymerica Sinica;2004-02
8 CHEN Fuping,HU Qiaoling,CHEN Liang,LI Baoqiang,SHEN Jiacong(Institute of Polymer Composites,Zhejiang University,Hangzhou 310027);PREPARATION OF MAGNETIC IRON OXIDE/HYDROXYAPATITE/CHITOSAN RODS BY in situ PRECIPITATION[J];Acta Polymerica Sinica;2006-06
9 L Jia,HU Qiaoling,SHEN Jiacong (Institute of Polymer Composites,Zhejiang University,Hangzhou 310027);THE EFFECT OF WATER STATES ON MECHANICAL PROPERTIES OF 3-DIMENSIONAL CHITOSAN MATERIALS[J];Acta Polymerica Sinica;2006-08
10 LI Hong,ZHU Min-ying,LI Li-hua,ZHOU Chang-ren(Department of materials science and engineering,Jinan University Guangzhou 510632,China);Preparation of in situ-deposited hydrxyoapatite on chitosan scaffold[J];Journal of Functional Materials;2006-06
Chinese Journal Full-text Database 10 Hits
1 ZHU Jun~(1,2),SHEN Yu-hua~(1,3),XIE An-jian~(1,3),ZHANG Li ~(1,2),MA Dong~(1) (1.Department of Chemisty of Anhui University, Hefei 230039,China; 2.Department of Chemisty & Biology,Suzhou college,Suzhou 234000,China; 3.State Key Laboratory of Coordination Chemistry,Nanjing University,Nanjing 210093,China);Study on the growth of calcium oxalate crystal in agar-gel system[J];Journal of Anhui University(Natural Sciences);2005-02
2 Li Xinyun Zhang Baoquan Bai Xiaojun ( Department of Chemistry and Environmental Engineering );Removing Lead and Cadimum in Wastewater with Synthtic Hydroxylapatite[J];Journal of Beijing Polytechnic University;1993-04
3 XU Yi~(1,2) , QIN Chuan-jiang~2 , ZHAO Bai-sen~2 , HUANG Nan~1(1.School of Materials Science and Engineering,Southwest Jiaotong University , Chengdu 6100310, China;2.Chongqing Industry Ploytechnic College , Chongqing 400050, China);Interface Structure on Hydroxyapatite Coating Based on Titanium and Designing of Functional Gradient Coating[J];Surface Technology;2005-01
4 Wang Hai ting,CHEN Lei,JIN xue Ling, ZHU Hai tao (Department of Applied Chemistry,Qingdao Institute of Chemical Technology,Qingdao 266042);The Research and Development of Hydroxyapatite in the Bioceramics[J];Shandong Ceramics;2002-02
5 ZHANG Fahao; WU Man; XU Shanjin; WANG Kui(Department of Inorganic Chemistry. Beijing Medical University 100083);STUDY OF CALCIUM PHOSPHATES FORMATION IN COLLAGEN GELS[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1996-02
6 LIU Ru-guang, LI Jia-jun, ZHAO Nai-qin (School of Material Science and Engineering, Tianjin University, Tianjin 300072, China);Hydroxyapatite Coating Synthesized by Electrochemical Methods[J];Materials Protection;2004-07
7 Shao Xin Tian Jun Xue Qunji Ma Chunlin( State Key Laboratory of Solid Lubrication,Lanzhou Institute of Chemical Physics,the Chinese Acaemy of Sciences, Lanzhou 73000,China; Department of Chemistry,Liaocheng Normal University,Liaocheng 252000,China);Preparation, Properties and Applications of Organic-Inorganic Nanocomposites[J];Materials Review;2001-01
8 HUANG Zhiliang LIU Yu WANG Dawei ZHANG Yu XU Huanyan (Department of Materials Engineering,Wuhan Institute of Chemical Technology,Wuhan 430073; Institute of Resource and Environment,South Central University ,Changsha 410083);Collagen Protein Template-Mediated Biomimetic Synthesis of Nano Flake Hydroxyapatite (HAP)[J];Materials Review;2002-10
9 LI Yan (College of Science,Civil Aviation University of China,Tianjin 300300);Synthesis of Hydroxyapatite Biomaterials[J];Materials Review;2003-11
10 XU Guofu1,MOU Shenzhou1, LIAO Susan2, Fumio Watari2 (1 School of Materials Science and Engineering, Central South University, Changsha 410083, China; 2 Hokkaido University, Sapporo 060-8586, Japan);The Preparation and Characterization of a Carbonated Hydroxyapatite/Collagen Composite at the Room Temperature[J];Materials Review;2006-08
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 ;Evaluation of curative effect of chitosan-ascorbate in treat ment of chronic periodontitis[J];Journal of Jilin University(Medicine Edition);2009-03
2 LI Xiaohong(Department of Medical Technology,Baotou Medical College,Baotou 014010,China);A Study of Preparation and Characterization of Nano-hydroxyapatite/Chitosan Artificial Bone Composite Material[J];Journal of Baotou Medical College;2008-01
3 FENG Qiang, MIN Si-jia, ZHANG Hai-ping, GAO Xin, WANG Qi-chong, ZHU Liang-jun (Institute of Applied Bioresources, College of Animal Science, Zhejiang University, Hangzhou 310029, China);Advance of Research on Hydroxyapatite and Its Composite in Bone Tissue Engineering[J];Bulletin of Sericulture;2008-01
4 SHI Guang,SUN Lin,LUO Sui-lian,SUN Feng-qiang(School of Chemistry and Environment,South China Normal University,Guangzhou 510006,China);Preparation and properties research of nanocomposite film based chitosan and nanocrystal cellulose[J];Materials Research and Application;2008-04
5 CHENG Xian-miao1,2,LI Yu-bao1,ZHANG Li1,ZUO Yi1,LI Ji-dong1,2,LIAO Jian-guo1 (1.Analytical and Testing Center,Research Center of Nano-Biomaterial,Sichuan University,Chengdu 610064,China; 2.College of Chemistry,Sichuan University,Chengdu 610064,China);Preparation and characterization of nano-hydroxyapatie/chitosan composite membrane for guided bone regeneration[J];Journal of Functional Materials;2008-06
6 LU Xiaoying,WANG Xiuhong,LIU Zhi,WENG Jie(Key Lab of Advanced Technologies of Materials(Ministry of Education),School of Materials Science & Engineering,Southwest Jiaotong University,Chengdu 610031,China);Effect of pH value on the nano-hydroxyapatite/chitosan composites via in-situ hydrothermal precipitation[J];Acta Materiae Compositae Sinica;2009-04
7 WU Fang,DAI Bo-chuan,LI Wei-zu(College of Pharmacy;Fujian Medical University;Fuzhou 350004,China);Preparation and investigation of nano-hydroxyapatite/chitosan-algin composite material[J];Strait Pharmaceutical Journal;2009-03
8 MA Zhi-wei1a,ZHANG Bang-le1b,HE Wei1b,WU Zhi-fen1a,SUN Ji-yuan1b,WANG Qin-tao1a(a.College of Stomatology;b.School of Pharmacy,1.Fourth Military Medical University,Xi'an 710032,China);Synthesis of a Novel Chitosan Grafted with β-cyclodextrin[J];Chinese Journal of Synthetic Chemistry;2007-05
9 LIU Yuangang1,ZHOU Changren2(1 College of Materials Science & Engineering,Huaqiao University,Quanzhou 362021,Fujian,China;2 Laboratory of Biomaterials Research,Jinan University,Guangzhou 510632,Guangdong,China);Preparation and characterization of functional lysozyme loaded microspheres[J];Chemical Industry and Engineering Progress;2007-12
10 WANG Xuejun,SONG Guojun,LOU Tao,PENG Wenjuan(School of Chemistry,Chemical Engineering & Environmental Science,Qingdao University,Qingdao 266071,Shandong,China);Preparation and characterization of nano-fibrous PLLA composite scaffold with nano-HAP[J];Chemical Industry and Engineering Progress;2009-04
【Secondary Citations】
Chinese Journal Full-text Database 5 Hits
1 Chu Chenglin et al;Advancement of Hydroxyapatite(HA)Biological Composites[J];Materials Review;1999-02
2 Liu Yanru Chen Sheng Yu Ping (Institute of Polymer Science);The Preparation of Water soluble Low molecular Weight Chitosan and the Complex with Calcium Ions[J];JOURNAL OF FUJIAN TEACHERS UNIVERSITY(NATURAL SCIENCE);1997-03
3 ZHENG Hua, DU Yu-Min, YU Jia-Hui, XIAO Ling (Department of Environmental Science, Wuhan University, Wuhan 430072, China);The Properties and Preparation of Crosslinked Chitosan Films[J];CHEMICAL RESEARCH IN CHINESE UNIVERSITIES;2000-05
4 Aiqin WANG,Peiqing ZHAO,Xiaojun GAO and Xianda YU Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,730000 Lanzhou;Study on Chitosan Zn(Ⅱ) Complex by IR Spectroscopy[J];SPECTROSCOPY AND SPECTRAL ANALYSIS;1999-06
5 XIE Zhihai QIANG Yonggang LANG Huiyun YUAN Hongan Department of Chemistry, Northwest University, Xi抋n 710069;SYNTHESIS AND CHARACTERIZATION OF Fe(II)-CHITOSAN COORDINATION POLYMER[J];Ion Exchange and Adsorption;2002-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved