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《Chemical Research In Chinese Universities》 2005-09
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Synthesis and Characterization of Electro-active and Biodegradable Block Copolymer of Aniline Pentamer with Polylactide

HUANG Li-Hong+{1,2}, HU Jun+{1,2}, ZHUANG Xiu-Li+{1,2}, MA Jia+{1,2}, CHEN Xue-Si+{1,2*}, JING Xia-Bin+{1,2}, GUO Yi+3, LI Meng-Yan+3, Peter I. Lelkes+3, WEI Yen+{3*}(1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; 2. The Graduate School of Chinese Academy of Sciences, Beijing 100039, China; 3. Department of Chemistry, Drexel University, PA 19104, USA)  
Every slight movement of human body, such as beat of heart, contract of muscles, thinking of brain, is associated with bioelectricity. In search for a neural conducting tissue engineering material which can {ideally} conduct bioelectrical signals in vivo, the block copolymer of polylactide(PLA) and aniline pentamera material which is electro-active, remarkably biocompatible and biodegradable, was designed and synthesized. The aniline pentamer is similar with polyaniline in electrical chemical properties, but more soluble than the latter. The copolymer is prepared by condensation polymerization between carboxyl-capped aniline pentamer and {dihydroxyl}-capped PLA, with N,N′-dicyclohexylcarbodiimide(DCC) as a condensing agent. The co-polymerization of aniline pentamer and PLA can not only reduce the toxicity of aniline pentamer, but also make the {material} easily to degrade and excrete from the body. These properties of the copolymer provide a favorable prospect in biomedical application in vivo. The synthesized material is investigated by FTIR, {}+1H NMR, UV, and cyclic voltammetric measurements.
【Fund】: 国家自然科学基金(批准号:50273038 20274028);; 国家杰出青年基金(批准号:50425309)资助.
【CateGory Index】: O631;
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