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《Chemical Journal of Chinese Universities》 2007-02
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Difference Analysis of Mass Spectra and Its Application to Research of Chinese Multiherb Remedy

RAN Xiao-Rong1,YANG Hui-Hua1,LIANG Qiong-Lin1,CHEN Jun1,WANG YiMing1,LUO Guo-An1*,LI Ping2,LI Ke-Ming2,CHEN Yu-Wu2(1.Department of Chemistry,Tsinghua University,Beijing 100084,China;2.Clinical Medicinal Research Institute,China-Japan Friendship Hospital,Beijing 100029,China)  
The constituents in effective groups of Chinese multiherb remedy possess the similar chemical and structural characters,and the same neutral loss under collisional induced dissociation(CID).Based on this,the fingerprints of the multiherb remedy and the effective extracts were established by using HPLC-ESI-MSn in this paper,the information of retention time,molecular weights and the fragment information was compared to confirm the attribution of effective constituents to the peaks in the fingerprint of Chinese multiherb remedy,then,the difference analysis of mass spectra was employed to deal with the fragment data for rapidly identifying the effective constituents according to the neutral loss.Taking Chinese multiherb remedy Chailin-tang for example,its effective fractions flavonoids in Radix Scutellariae and Saikosaponins in Radix bupleuriand were studied.
【Fund】: 国家“九七三”计划项目中医理论专项(批准号:2005CB523503);; 科技部“十五”攻关项目(批准号:2004BA721A13);; 国家“九七三”计划项目(批准号:2001CB510305);; 清华基础研究基金(批准号:JCqn2005038)资助
【CateGory Index】: R289
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