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《Chemical Journal of Chinese Universities》 2008-10
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Proparation and Characterization of Stereoselective L-Histidine Imprinted Microspheres

ZHANG Zhao-Hui1,2,ZHANG Hua-Bin1,WU Yu-Fang1,LIU Li1,LI Hui1,2,YAO Shou-Zhuo2(1.College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,China;2.State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University,Changsha 410082,China)  
Stereoselective L-histidine imprinted microspheres(MIMs) were synthesized with precipitation polymerization using L-His as the template,methacrylic acid(MAA) as the functional monomer,ethylene glycol di-methacrylate(EGDMA) as the cross-linker,2,2′-azobis-isobutyronitrile(AIBN) as the initiator,and water-acetonitrile microemulsion as dispersant.Equilibrium binding experiment and HPLC experiment were conducted to discuss the binding performance and the results show that two kinds binding sites is observed for the imprinted microspheres binding to the template with the maximum apparent binding constant 33.04 and 24.16 μmol/g,respectively.These imprinted microspheres exhibit an excellent stereoselectivity for L-histidine with the selective factor 2.14.The properties of polymers were characterized by IR spectra,thermalgravities analysis,and XRD,and the results indicate that the MIMs exhibit an excellent stability.
【Fund】: 湖南省自然科学基金(批准号:08JJ4004);; 湖南省教育厅优秀青年基金(批准号:07B061)资助
【CateGory Index】: O657.7
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