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《Chemical Journal of Chinese Universities》 2011-07
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Biotransformation of Aconitum Alkaloids Before and After the Combination of Radix Aconiti Preparata by Rat Intestinal Flora Using Semiquantitative Analysis Method of Electrospray Ionization Mass Spectrometry

WANG Xi-Ye1,2,PI Zi-Feng1,LIU Wen-Long1,SONG Feng-Rui1, LIU Zhi-Qiang1,LIU Shu-Ying1(1.Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China; 2.Graduate School of the Chinese Academy of Science,Beijng 100049,China)  
The biotransformation of diester-diterpenoid alkaloid,monoester-diterpenoid alkaloid and lipo-alkaloid in the decoctions of Chinese medicine pairs by rat intestinal flora was studied using electrospray ionization tandem mass spectrometry.The semiquantitative method of mass spectrometry was established for the analysis of aconitum alkaloids before and after biotransformation.The content changes of aconitum alkaloids caused by rat intestinal flora was analyzed in the biotransformation process of the decoctions of Radix Aconiti Preparata with Bulbus Fritillariae Thunbergii,Rhizoma Pinelliae Preparatum and Ampelopsis Japonica.The results showed that after the combination Bulbus Fritillariae Thunbergii increased the content of diester-diterpenoid alkaloids,and Rhizoma Pinelliae Preparatum reduced the content of diester-diterpenoid alkaloids,and Ampelopsis Japonica almost has no effect for the content of diester-diterpenoid alkaloids in decoction;the rat intestinal flora can more reduce the toxicity of diester-diterpenoid alkaloids and increase the content of lipo-alkaloids.The mechanism of combination and biotransformation of traditional Chinese medicine was proposed by the analysis of the content changes of aconitum alkaloids in Chinese medicine pairs.
【Fund】: 国家“九七三”计划中医理论专项基金(批准号:2006CB504706);; 国家自然科学基金(批准号:81073040)资助
【CateGory Index】: R285
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