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《Chemical Journal of Chinese Universities》 2012-01
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Blood Compatibility Improvement of Titanium via Self-polymerization of Dopamine and Covalent Graft of Heparin

XIE Bing,LI Gui-Cai,DAI Lu,YANG Ping*,HUANG Nan (Key Laboratory for Advanced Technology of Materials,Ministry of Education, Southwest Jiaotong University,Chengdu 610031,China)  
elf-polymerization of dopamine and immobilization of heparin were applied for surface-modification of titanium in order to improve its blood compatibility.Surface modification was developed via self-polymerization of dopamine and covalent graft of heparin.Surface elemental composition was analyzed qualitatively by X-ray photoelectron spectroscopy(XPS).Surface heparin content was detected by toluidine blue O(TBO).Surface hydrophilicity and hydrophobicity were characterized by water contact angle measurement.Hemolysis rate test,which was applied for detection ofhemolytic ability,was combined with activated partial thromboplastin time test(APTT) and platelet adhesion test to evaluate blood compatibility.The results showed that self-polymerization of dopamine was achieved on titanium surface.Heparin was successfully immobilized onto polydopamine layer by covalent graft.The heparin-modified surface could result in a significantly improved hydrophilicity,low hemolysis rate,prolonged APTT and a remarkablely decrease both in adhesion amount and activation degree of platelet.The blood compatibility of titanium could be significantly improved by the method of self-polymerization of dopamine and covalent graft of heparin.This study provides potential application for cardiovascular implants materials with anticoagulant properties.
【Fund】: 中央高校基本科研业务费专项资金(批准号:2010XS32);; 国家“九七三”计划项目(批准号:2005CB623904);; 国家自然科学基金(批准号:30870629)资助
【CateGory Index】: R318.08
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【Citations】
Chinese Journal Full-text Database 4 Hits
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【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 WU Fei,LI Hong-hua,WU Qiang.Department of Neurology,Wuhan General Hospital of Guangzhou Military Region,Wuhan 430070,China;Anticoagulant Therapy for Cerebral Venous Thrombosis and Prognosis Analysis[J];Neural Injury and Functional Reconstruction;2009-01
2 DUAN Dong-xia1,2,LIN Cun-guo2,ZHENG Ji-xong2(1.College of Marine Life Science,Ocean University of China,Qingdao 266003,China;2.State Key Lab for Marine Corrosion and Protection,Qingdao Branch of Luoyang Ship Material Research Institute,Qingdao 266071,China);Screen and identification of marine bacteria with antifouling property[J];Marine Environmental Science;2010-05
3 TANG Qi,SUN Xiang-ying,LI Fang(College of Material Science and Engineering,Huaqiao University,Quanzhou 362021,China);Formation of Thioflavin T Excimer Induced by Anionic Polyelectrolyte and Its Influencing Factors[J];Journal of Huaqiao University(Natural Science);2011-06
4 FANG Liang,HU Jing-xin,LIU Guo-hui,DENG Guang-fei(Department of Physiology,Guangzhou Medical College,Guangzhou,510182,P.R.China);Therapeutic effect of low molecular weight heparin in MPTP-treated mice and a possible mechanism[J];Progress in Modern Biomedicine;2009-20
5 SHEN Jiang-nan,CHEN Yong-sheng,RUAN Hui-min(College of Chemical Engineering and Materials Science,Zhejiang University of Technology,Hangzhou 310014,China);Net-shaped membrane preparation of PVDF and its BSA absorption performance[J];Modern Chemical Industry;2010-S2
6 Liu Hua-dong1,Dong Shao-hong2,Liao Yu-hua1,Jiang Xin21Department of Cardiology,Xiehe Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China;2Department of Cardiology,Shenzhen People’s Hospital,Shenzhen 518020,Guangdong Province,China;Low-molecular-weight heparin versus unfractionated heparin in construction of rat carotid arterial injury model[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-30
7 Chen Wen-ping1,Zhan Hong-bing2,Li Zhao-hui3,Feng Miao2,Liu Wei2,Xiao Yong21College of Materials Science,2College of Material Science and Engineering,Fuzhou University,Fuzhou 350108,Fujian Province,China;3Department of Vascular Surgery,Zhongshan Hospital,Xiamen University,Xiamen 361004,Fujian Province,China;Preparation of 3,4-Dihydroxy-L-phenylalanine modified organic-inorganic hybrid coatings for drug eluting stents[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2010-38
8 ;联合应用肝素控制子痫抽搐3例疗效分析[J];Chinese Journal of Practical Gynecology and Obstetrics;2011-01
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