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NMR Studies of Gd(DTPA BIN) in Human Serum Albumin Solution

LI Xin Yu, ZHANG Shan Rong, JING Feng Ying, WU Yi Jie, PEI Feng Kui * (The Key Laboratory of Applied Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022)  
Stable gadolinium complexes, such as Gd(DTPA) and Gd(DOTA), are usually used as the contrast agents for magnetic resonance imaging(MRI). Reported here are the enhanced relaxation properties of a novel gadolinium complex, diethylene triaminopentaacetate bis(isoniazid) Gd(DTPA BIN) , in aqueous and in human serum albumin(HSA) solution, which indicates that (1) two Gd(DTPA BIN) can integrate non covalently with one HSA with an equilibrium constant of 0.02 mmol -2 \5L 2; (2) the relaxivities are 3.28 and 4.92 mmol -1 \5L\5s -1 for the free Gd(DTPA BIN) and the Gd(DTPA BIN) 2 HSA conjugator, respectively; (3) the rotational correlation time of protein conjugator is notably higher than that of the free complex. The above results may imply that Gd(DTPA BIN) has a higher tissue selectivity than that of its parent Gd(DTPA).
【Fund】: 中国科学院“九五”预研基金
【CateGory Index】: O657.2
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