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《High Voltage Engineering》 2009-05
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Research Progress and Prospect of Fracture Healing Using Pulsed Electromagnetic Fields (PEMFs)

MI Yan1,HU Jin-xing2,LUO Xiao1,LI Cheng-xiang1,YAO Chen-guo1,SUN Cai-xin1(1. State Key Laboratory of Power Transmission Equipment & System Security and New Technology,Chongqing University,Chongqing 400044,China; 2. Chongqing Urban Power Supply Bureau,Chongqing Electric Power Company,Chongqing 400013,China)  
Fracture is a kind of common disease in clinical field,but there are many difficult and complicated cases such as bone nonunion. The traditional treatment relies on bones transferring or internal fixation,which leads to a high ratio of risk to cure,and brings extreme pains to patients. In 1970s,Mr. Bassett from Colombia University took the lead in using pulsed electromagnetic fields (PEMFs) for fracture therapy,and confirmed PEMFs could help to heal fractures. PEMFs presents many perfect performances in fracture treatments such as that it causes no other injury,is easy to be operated,has wide application,and has no complications,etc.. PEMFs’ positive performances are free from time of fractures,injury of skin or nerve,age and gender of patients,and times of failure in operation,etc.,especially for local infection. During last 30 years,as the non-invasive therapeutics,PEMFs has been applied to clinical medicine successfully with perfect results. However,it’s functioning mechanism is still unclear,mainly includes piezoelectriceffect theory,calcium ion deposition theory and secondary messengers theory. It’s therapeutic efficacy is also affected by PEMFs’ parameters,such as frequency,intensity and wave form.This paper presents the development of PEMFs’ positive performance in fractures treatments through following four aspects: cell experiment study,animal experiment study,clinical application study,and functioning mechanism,analyses all factors that affect PEMFs’ performance,and then expands several issues needing further study and future development of PEMFs application in fracture therapy.
【Fund】: 国家自然科学基金重点项目(50637020)~~
【CateGory Index】: R683
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