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《Academic Journal of Guangdong College of Pharmacy》 2003-01
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Experimental study on anti-aging effect of Ginsenosides on skin of the aging model mice induced by D-galactose

WANG Hong li 1, WU Tie 2, WU Zhi hua 2, ZHU Yong xiang 3, GUO Qi jie 1 (1.Department of Dermatology, Guangdong College of Pharmacy, Guangzhou,Guangdong 510224; 2.Department of Pharmacology, Guangdong Medical College, Zhanjiang,Guangdong 524023)  
Objectives: To investigate the anti aging effect of Ginsenosides on skin. Methods: The aging mice model were established by subcutaneous administration with a dose of D galactose(1000 mg/kg·d -1 ) to female mice for 6 weeks. In the mean time,the mice received Ginsenosides(100 mg/kg·d -1 or 50 mg/kg·d -1 ) by intragastric administration. After 42 days, the SOD activity, the MDA and hydroxyproline contents in skin and the CAT and GSH Px activities in whole blood were determined. Results: The results showed that with the dosage of 100 mg/kg·d -1 Ginsenosides could significantly increase the SOD activity in skin and the CAT and GSH Px activities in whole blood,decrease the content of MDA in skin and increase the gydroxyproline content of dermal tissue in model mice. Conclusions: Ginsenosides(100 mg/kg·d -1 ) has obvious anti aging effects on aging mice's skin.
【CateGory Index】: R285.5
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