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《Academic Journal of Guangdong College of Pharmacy》 2004-06
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Determination of 5 anthraquinones in rhubarb extracts by HPLC

ZHENG Zhi-hua 1,ZHU Chen-chen 2 (1.Guangdong Pharmaceutical Association, Guangzhou 510080,China; 2.New Drug Research & Development Center of Guangzhou University, Guangzhou 510405,China)  
Objective to determine 5 anthraquinones such as chrysophanol, rhein, aloe emodin, emodin and physcion in rhubarb extracts by solvent extraction and SFE-CO 2. Methods CHCl 3 was used to extract free anthraquinones by ultrasonic vibration; conjugated anthraquinones in residue was hydrolyzed and then extracted by thermal reflux in CHCl 3. The analytical column was Allitima RP C 18 (250×4.6 mm, 5 μm). The mobile phase consisted of 0.1%TFA-HCN(17∶83). The flow rate was 1.0 mL/min. The UV detection wavelength was 280 nm and the reference wavelength was 600 nm. The column temperature was 25 ℃. Results considering the extracting rate of 5 anthraquinones, SFE-CO 2 was better than solvent extraction.
【Fund】: 国家自然科学基金资助项目 (编号为 3980 0 196 )
【CateGory Index】: R284.1
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