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《Journal of Guangdong College of Pharmacy》 2006-03
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HPLC assay for silver sulfadiazine in silver sulfadiazine cream

KANG Li-hong,ZHONG Hui-min(Jiangmen Hengjian Pharmaceutical Co.,Ltd.,Jiangmen 529000,China)  
Objective To establish a method for content determination of silver sulfadiazine in silver sulfadiazine cream.Methods HPLC analysis was performed on an Aichrom C_(18) column(250 mm×4.6 mm,5 μm).The mobile phase consisted 0.1% phosphoric acid-acetonitrile(92:8)and the flow rate was 1.0 mL/min.The detective wavelength was at 254 nm and column temperature 30 ℃.ResultsThe calibration curve showed a good linear relationship in the range of 20-300 mg/L(r=0.9999)for silver sulfadiazine.The average recovery of silver sulfadiazine was 99.6%(RSD=1.06,n=5).Conclusion The method is simple,sensitive,reproducible and suitable for quality control of the cream.
【Key Words】: HPLC silver sulfadiazine cream silver sulfadiazine
【CateGory Index】: R927
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 LI Yue-Ling,ZHENG Qi-Kun,HUANG Zuo-Jun(Guangzhou Red Cross Hospital,Guangdong Guangzhou 510220,China);Determination of the content and the related substances of silver sulfadiazine gel by HPLC[J];Chinese Journal of Hospital Pharmacy;2004-08
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 WU Ji-Yu,WANG Zhi-qiang,HUANG Xue-sun(The First Affiliated Hospital Of Wenzhou Medical College,Zhejiang Wenzhou 325000,China);Comparision of two methods for the content determination of sulfadiazine silver embrocation[J];Strait Pharmaceutical Journal;2010-03
2 GU Shu-yi~1 LI Yue-ling~1 BI Qi-li~1 ZHONG Yan-ling~2(1.Cuangzhou Red Cross Hospital,Guangzhou 510220,China2.Guangdong Pharmaceutical University,Guangzhou 510006,China);Quantitative determination of total sulfadiazine and sulfadiazine zinc in Silver zine gel by spectrophotometry[J];Chinese Journal of Pharmaceutical Analysis;2008-11
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