Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Guangdong College of Pharmacy》 2007-02
Add to Favorite Get Latest Update

Protective effects of breviscapine phosphatidylcholine complex against cerebral ischemia reperfusion injury in rats

YU En-xi1,WANG Fang2,JIAN Zhi-hong2(1.Dept.of Pharmacology,Hubei Institute for Drug Control,Wuhan,Hubei 430064,China;2.People's Hospital of Wuhan University,Wuhan,Hubei 430060,China)  
Objective To study the protective effects of breviscapine phosphatidylcholine complex(Ber-PC) against brain injury in rats undergone focal ischemia reperfusion.Methods Wistar rats were treated with Ber-PC for 14 days and were subjected to focal ischemia reperfusion by middle cerebral artery occlusion(MCAO) using intraluminal thread.After 2 hours of MCAO reperfusion was allowed by retracting the thread.The nerve symptoms were observed after 1 hour of reperfusion and the infracted area,the level of MDA,the activity of SOD,and GSH-PX in ischemic brain tissue were observed after 24 hours.Results Ber-PC could improve behavior disorder induced by MCAO and reduce brain infracted area through increasing the activity of SOD and GSH-PX,decreasing the level of MDA in brain tissue.Conclusion Ber-PC could protect against focal brain injury induced by reperfusion injury in middle cerebral artery of rats and could be a promising product.
【CateGory Index】: R965
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 Wan Haitong,Wang Yu Zhejiang College of TCM,Hangzhou(310053);Review on Breviscapine in Treating Cerebral Ischemia[J];;2006-01
2 HE Wei ZENG Fan-Dian(Department of Pharmacology, Gangnan Medical College, Gangzhou 341000) (Institute of Clinical Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030);Effect of Breviscapine on Ischemic Cerebrovascular Disease and Its Clinical Investigation[J];The Chinese Journal of Clinical Pharmacology;2002-06
3 GE Qing Hua 1, ZHOU Zhen 1, ZHI Xiao Jin 1, MA Li Li 1, CHEN Xiu Hua 2 (1. National Pharmaceutical Engineering Research Center; 2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200437);Pharmacokinetics and Absolute Bioavailability of Breviscapine in Beagle Dogs[J];Chinese Journal of Pharmaceuticals;2003-12
Chinese Journal Full-text Database 10 Hits
1 Gui Canlin,Chen Hua TCM Hospital of Lin'an City,Zhejiang Province(311300);SHRD Injection and Nitroglycerin Treat Non-ST Rise MI(myocardial infarction)[J];Journal of Zhejiang Chinese Medical University;2011-06
2 LI Ben,CHEN Jun-ping,ZHONG Ling,DUAN Xiao-hong,GUO Jian-wen,CAI Ye-feng. Department of Pharmacy,the Guangdong Provincial Haspital of Traditional Chinese Medicine,Guangzhou 510120,China;The interaction between the active components of Dengzhanshengmai Capsule and CYP450 enzymes in rats in vitro[J];Guangdong Medical Journal;2011-24
3 ZHOU Rong-Guang YAN Ze-Yua ZHAO Jia-Qiang XU Yongb(Institute for Drug Research and Development of Kunming Pharmaceutical Corporation,Kunming 650100,P.R.China)a(The Chemical Research Institute of Yunnan Province,Kunming 650228,P.R.China)b(Department of Pharmacology of TCM,Yunnan University of TCM,Kunming 650500,P.R.China);Preparation,Purification and Structural Characterization of Scutellarein[J];Chinese Journal of Spectroscopy Laboratory;2011-05
4 CAO Li-ming(Hospital,Southwest University,Chengdu 610000,China);Clinical Observation on Fleabane and Xiangdan Injections to Cure Cervical Vertigo[J];Health Medicine Research and Practice;2009-02
5 ZHANG Wei,XING Fengjing,FU Xiaozhong,LAN Yanyu,WANG Aimin,WANG Yonglin,WU Chungao,LI Jing,ZHOU Wen,LIU Ying(School of Pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China);Synthesis of L-amino Acid Ester Prodrug of Scutellarin[J];Journal of Guiyang Medical College;2011-02
6 LI Jing,ZHOU Wen,LIU Ying,FU Xiaozhong,OU Yu,LAN Yanyu,WANG Aimin,WANG Yonglin (School of Pharmacology,Guiyang Medical College,Guiyang 550004,Guizhou,China);Synthesis of 4'-N,N-Bis-substituted Aminomethylation Benzoate Ether Prodrug of Scutellarein Aglycone[J];Journal of Guiyang Medical College;2011-05
7 Zhang Xinzhan1,Wang Aijie2,Sui Zaiyun2(1.Central Hospita of Shandong Xinwen Mining Group,Shandong,Laiwu 271103;2.Institute of Traditional Chinese Medicine of Shandong Province,Shandong,Jinan 250014);Effects of Breviscapine on SOD,MDA,NO of rats with Cerebral Ischemia-reperfusion Injury[J];Henan Traditional Chinese Medicine;2009-10
8 LI Jian1),DONG Yan-qin1),LI Chen1),ZHANG Xuan1),WANG Yun-feng2),WANG Dian-hua1) (1)Yunnan Pharmacological Laboratory of Natural Products,Kunming Medical University,Kunming Yunnan 650031;2)Dept. of Otolarygology,EENT Hospital of Shanghai Medical College of Fudan University,Shanghai 200032,China);Effects of Breviscapine Liposomes for Pulmonary Delivery System on Expression of Protein Tissue Factor in Acute Lung Injury in Rats[J];Journal of Kunming Medical University;2008-03
9 RONG Na-na1),YANG Zhao-xiang2),ZHANG Wei2)(1)School of Pharmacy,Kunming Medical University,Kunming Yunnan 650031;2)Institute for Drug Research and Development of Kunming Pharmaceutical Corporation,Kunming Yunnan 650100,China);Determination of the Apparent Oil-water Distribution Coefficient of Scutellarin and Scutrllarein[J];Journal of Kunming Medical University;2011-05
10 SHEN Teng~1 YU Yunqiu~2 WENG Weiyu~1 LI Ni~2 HUANG Zhaochang~3 CAI Jia~1 HUANG Jianming~2 1 Department of Pharrnaceutics, 2 Department of Pharmaceutic Analysis,School of Pharmacy,Fudan University,Shanghai 200032,China; 3 Kunming Pharmaceutical Corporation Ltd.,Kunming 650100,China;Absolute bioavailability of breviscapine sustained release tablet in rabbit[J];Chinese Journal of Clinical Pharmacy;2008-01
China Proceedings of conference Full-text Database 3 Hits
1 YOU Hai-sheng1,DONG Ya-lin1, XING Jian-Feng2, ZHANG Chun-ling3, WANG Mao-yi1 (1.Department of pharmacy, The first affiliated hospital of Medical School, Xi’an Jiaotong University, Xi’an, 710061, China; 2 .Xi’an Jiaotong University of Medical School Xi’an, 710061, China;.3.Red cross hospital Xi’an, 710061, China );The pharmacokinetic and tissues distribution study of scutellarin in rat[A];[C];2006
2 SONG Yan,ZHANG Hong-mei,MA Jian-jian,CHE Qing-ming,LI Chang-ling (School of Pharmaceutical Sciences,Peking University Health Science Center,Beijing100191,China);Protection of Scutellarein on cerebral ischemia in rats[A];[C];2010
3 SHI Seng-lin~1,WU Jin-jin~2,ZHANG Xiao-Dong~1,Dai Wen-yun~1,GE wei-hong~1,LI Chang-yu~1 (1 College of Pharmacy,Zhejiang Chinese Medical University,Hangzhou,310053,China;2.Hangzhou NO.4 hospital,Hangzhou 310007,China);Study on Pharmacokinetics of Breviscapine administered by different routes to rats[A];[C];2009
Chinese Journal Full-text Database 10 Hits
1 Ruan Zhipeng,Yu Weidong Department of Pharmacy,Putian University,Putian Fujian;Experimental Study on Anti-inflammation Influence of Scutellarin[J];Journal of Changzhi Medical College;2004-02
2 ;中老年心脑血管疾病的预防及治疗[J];Contemporary Medicine;2011-25
3 WAN Qi-jun HE Yong-cheng LIU Jin et al ( The Second People' s Hospital of Shenzhen , Shenzhen 518035, China);Effects of Dengzhanhua Injection on Hemorrheology and Renal Function inPatients with Chronic Renal Failure[J];Journal of Henan Medical College For Staff and Workers;2003-01
4 HAN Feng1,YU Chen-ye2,DU Xiao-ming1,ZHAO Li-mei1*(1.Department of Pharmacy,Shengjing Hospital of China Medical University,Shenyang 110004,China;2.Shenyang Pharmaceutical University,Shenyang 110016,China);Investigation on antihyperlipidemics intervention of high risk hospital patients with angiocardiopathy and cerebrovascular disease[J];Practical Pharmacy and Clinical Remedies;2012-10
5 ZHOU Chao-gui (College of Pharmy,Yantai University,Yantai 264003,China);Optimization of coating formulation of roxithromycin taste-masking by central composite design-response surface methodology[J];Qilu Pharmaceutical Affairs;2011-04
6 WANG Fen-juan, bAO Yong-cu, CHEN Qin-hua(National Pharmaceutical Engineering and research Center,China State Institute of Pharmaceutical Industry,Shanghai,201203);R & D advances of gastro-retentive drug delivery system[J];Shanghai Medical & Pharmaceutical Journal;2012-03
7 HAN Rui,ZOU Mei-juan,WANG Hui-ying,CHENG Gang(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Preparation of acyclovir gastric-floating tablets[J];Journal of Shenyang Pharmaceutical University;2011-01
8 CHEN Da-wei;ZHANG Yan-qing;ZOU Yan-shuang;LI Shu-bin;School of Pharmacy,Shenyang Pharmaceutical University;;Study on pharmacodynamics and pharmcokinetics of breviscapin sustained-release pellets in rabbits[J];Chinese Journal of Pharmaceutics(Online Edition);2003-02
9 JI Hai-ting;HAO Xiu-hua;ZHANG Chun-hai;School of Pharmacy,Jilin University;China-Japan Friendship Hospital Affiliated,Jilin University;;Optimization of formulation for colon-targeted tablets with sinomenine hydrochloride by central composite design-response surface method[J];Journal of Shenyang Pharmaceutical University;2014-07
10 LIU Yan-jie,XIANG Rong-wu(Matmatic Sector of Shenyang Pharmaceutical University,Shenyang 110016,China);Application of Central Composite Design/Response Surface Methodology in Pharmacy Experiment Design[J];Chinese Journal of Modern Applied Pharmacy;2007-06
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 QU You-zhi,ZHAO Yan-ling,ZHAO Wen-ying,GAO Guo-dong,XIA Tian (Deptartment of Neurosurgery,Tangdu Hospital,The Fourth Military Medical University,Shaanxi Xi'an 710038,China);PROTECTIVE EFFECTS OF ERIGERON INJECTION ON CEREBRAL ISCHEMIC AND REPERFUSION INJURY[J];Journal of Anhui Traditional Chinese Medical College;2001-03
2 ZHANG Xiao bing, PENG Dai yin, ZHU Man fang,ZHOU Ya Qiu, LIU Qing yun (Department of Pharmacy, Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);Protective Effect of Breviscapine Dropping Pill Against Focal Cerebral Ischemia Reperfusion Injury in Rats[J];Journal of Anhui Traditional Chinese Medical College;2003-01
3 Chen Xiaoxia,He Bing (Guangdong College of Pharmacy,Guangzhou,P.R.China 510224);Protective Effects of Breviscapine Against Cerebral Ischemia Reperfusion Injury in Rats[J];ACADEMIC JOURNAL OF GUANGDONG COLLEGE OF PHARMACY;1997-02
4 Zhang Yan,Chen Qun,Yan Xuejun,et al. Department of Anesthesiology,Wuxi Fourth People′s Hospital, Wuxi 214062 CHINA;Effect of erigeron on cerebral ischemia-reperfusion injury in gerbils[J];The Journal of Clinical Anesthesilolgy;2001-11
5 CHEN Kong-Ning. DONG Wei-Wei Department of Neurology, South-West Hospital (400038);Effect of Dengzhanhua on Neuronal Apoptosis Induced by Cerebral Ischemia[J];Chinese Journal of Clinical Neurosciences;2000-01
6 MIN Lian qiu 1,YUAN Jing 1,HE Chun 2,LUO Qing e 3,YANG Li 1,HOU Feng ying 1,ZHAO Xue zhong 3,ZHAO Pei xia 1 (1.Department of Neurology,1st Affiliated Hospital of Jinzhou Medical College,Jinzhou 121001,China; 2.Linghe District Hospital,Jinzh;Clinical Study on Effects of Breviscapin on Acute Cerebral Infarction[J];Liaoning Journal of Traditional Chinese Medicine;2001-02
7 Liu Fang,Su Desen,Li Sanming No.466 Hospital of PLA,Beijing 100089;Investigation in Complex between Ibuprofen and Egg Phosphocholine[J];Journal of Shenyang Pharmaceutical University;2000-06
8 QU You zhi,ZHAO Yan ling,GAO Guo dong, et al .(Department of Neurosurgery,Tangdu Hospital,Fourth Military Medical University,710038,China);Study on the effects of erigeron injection in prevention and treatment of cerebral ischemia and reperfusion injury[J];Medical Journal of National Defending Forces In Northwest China;2002-02
9 XU Ji-Min HUANG Zhen-Hua (Cardiovascular Research Room, Shanghai Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011);Erigeron breviscapus capsule in the treatment of cerebrovascular disorders in 74 patients[J];;1991-05
10 CHEN Qun, ZENG Yin Ming, WANG Jian Guo (Dept of Anesthesiology, Affiliated Hospital, Xuzhou Medical College, Xuzhou 221002);Protective role of breviscarpin on brain tissue and its effect on immunoreactivity of microtubule motor protein[J];Chinese Pharmacological Bulletin;2001-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved