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《Journal of Guangdong College of Pharmacy》 2007-02
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Protective effects of breviscapine phosphatidylcholine complex against cerebral ischemia reperfusion injury in rats

YU En-xi1,WANG Fang2,JIAN Zhi-hong2(1.Dept.of Pharmacology,Hubei Institute for Drug Control,Wuhan,Hubei 430064,China;2.People's Hospital of Wuhan University,Wuhan,Hubei 430060,China)  
Objective To study the protective effects of breviscapine phosphatidylcholine complex(Ber-PC) against brain injury in rats undergone focal ischemia reperfusion.Methods Wistar rats were treated with Ber-PC for 14 days and were subjected to focal ischemia reperfusion by middle cerebral artery occlusion(MCAO) using intraluminal thread.After 2 hours of MCAO reperfusion was allowed by retracting the thread.The nerve symptoms were observed after 1 hour of reperfusion and the infracted area,the level of MDA,the activity of SOD,and GSH-PX in ischemic brain tissue were observed after 24 hours.Results Ber-PC could improve behavior disorder induced by MCAO and reduce brain infracted area through increasing the activity of SOD and GSH-PX,decreasing the level of MDA in brain tissue.Conclusion Ber-PC could protect against focal brain injury induced by reperfusion injury in middle cerebral artery of rats and could be a promising product.
【CateGory Index】: R965
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