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《Journal of Guangdong College of Pharmacy》 2008-03
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Simultaneous determination of hydrochlorothiazide,dihydralazine sulfate and triamterene in compound hypoensive tablets by HPLC

PAN jing-lan (Guangzhou Xingqun Pharmaceutical Co.Ltd.,Guangzhou,Guangdong 510288,China)  
Objective To establish an HPLC method for simultaneous determination of hydrochlorothiazide,dihydralazine sulfate and triamterene in compound reserpine-triamterene tablets.Method Samples were analyzed on a reversed-phase CN column(4.6 mm × 250 mm,10 μm) with 0.01 mol/L sodium heptanesulfonate(adjusted with 20% H3PO4 to pH2.7)-acetonitrile(85∶15) as mobile phase.The flow rate was 1.0 mL/min and the detection wavelength 316 nm.Results The calibration curves were linear over the range of 60~180 μg/mL(r=0.999 9) for hydrochlorothiazide,dihydralazine sulfate and triamterene.The average recoveries were 100.2%(RSD=0.36%,n=9) for hydrochlorothiazide,100.1%(RSD=0.85%,n=9) for dihydralazine sulfate,and 100.3%(RSD=0.83%,n=9) for triamterene.Conclusion The method is simple,sensitive and accurate,which could be used for the quality control of compound reserpine-triamterene tablets.
【Key Words】: HPLC compound reserpine-triamterene tablets hydrochlorothiazide dihydralazine sulfate triamterene
【CateGory Index】: R927.2
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【References】
Chinese Journal Full-text Database 1 Hits
1 CHENG Zheng,WAN Qing,GUAN Yu-yun,WU Ling(Tongling Institute for Drug Control,Tongling,Anhui 244000,China);Determination of hydrochlorothiazide,promethazine hydrochloride and reserpine in compound reserpine tablets by HPLC[J];Anhui Medical and Pharmaceutical Journal;2010-01
【Citations】
Chinese Journal Full-text Database 1 Hits
1 CHE Bao-quan * (Beijing Institute for Drug Control, Beijing 100035, China);Determination of five components in compound hypotensive tablet by HPLC[J];Acta Pharmaceutica Sinica;2004-08
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 JI Wan-li1,ZHAO Jia-tai2(1.Shanxi Changzhi Institute for Drug Control,Changzhi 046000,China;2.Shanxi Taihang Pharmaceutical Co.Ltd,Changzhi 046000,China);Determination of dihydralazine sulfate in compound kendir tablets (II) by HPLC[J];Strait Pharmaceutical Journal;2008-01
2 Wanli Ji1, Jiatai Zhao2 (Shanxi Changzhi Institute for Drug Control, Changzhi 046000;Shanxi Taihang Pharmaceutical Co.Ltd, Changzhi 046000);Determination of Dihydralazine Sulfate of Compound Kendir Tablets (II) by HPLC[J];Life Science Instruments;2007-12
3 LIU Hai-ying HUANG Li YANG Ning MIAO Ai -dong SU Fang SHEN Zhen -hua (Institute tot Drug and Instrument Control of United Logistics Department of Beijing Command of PLA,Beijing 100071,China);HPLC determination of five characteristic constituents in compound pargyline tablets[J];Chinese Journal of Pharmaceutical Analysis;2008-08
4 XU Bo~1 CHANG Ling~1 GAO Ling~2(1.Guizhou Province Institute for Drug Control,Guiyang 550004,China;2.The Remin Hospital of Guizhou Province,Guiyang 550002,China);HPLC determination of vitaminB_1,vitaminB_6,pantothenic acid and hydrochlorothiazide in compound reserpine tablets[J];Chinese Journal of Pharmaceutical Analysis;2008-11
5 MAO Guifu,GUO Tao(Dept. of Pharmacy,The General Hospital of Shenyang Military Region,Shenyang 110016,China)MAO Guifu(Shenyang Pharmaceutical University,Shenyang 110016,China);Determination of Three Components in Compound Hypotensive Tablet by RP-HPLC[J];China Pharmacy;2007-22
6 GAO Qing, ZHANG Zhe, DAI Hong, CHE Bao-quan, GUO Hong-Zhu (Beijing Institute for Drug Control, Beijing 100035);Detection of Antihypertensive Agents Illegally Added in Traditional Chinese Medicine and Health Care Products by LC-MS/MS[J];Chinese Journal of Pharmaceuticals;2007-05
7 Wu Yanlin Lin Zhihua (Wuhan Institute for Drug Control,Wuhan 430012,China); Wang Yang (College of pharmacy,Tongji Medical College,Huazhong University of Science and Technology); Chen Shihui (Xianning Medical College);Determination the Contents of Four Components in Compound Reserpine Tablets by HPLC[J];China Pharmacist;2007-06
8 WANG Ying 1,2,WANG Wei-hong 1,NIE Lei1 (1.School of Pharmaceutical Sciences,Shandong University,Jinan 250012;2.Shandong Drug and Food Vocational College,Zibo 255011);Determination of Six Components in Compound Reserpine Tablets by Partial Least Square Method[J];Chinese Journal of Pharmaceuticals;2009-10
9 WU Hongying1,FAN Yufeng2(1.Institute for Food and Drug Control of Xinyang City,Xinyang 464000,China;2.Affiliated Hospital of Xinyang Polytech-nic of Henan Province,Xinyang 464000,China);Analysis of dihydralazine sulfate in compound reserpine tablets by reversed phase ion pair chromatograpy[J];China Modern Medicine;2009-16
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 WANG Zhen,SHI Qing-ping,DING Feng,XU Shan-chu (Department of Pharmacy,Affiliated Hospital of Bengbu Medical College,Bengbu 233004,Anhui Provice);Determination of related substances in pyritinol hydrochloride for injection by HPLC[J];Anhui Medical and Pharmaceutical Journal;2007-02
2 SUN Li(Wuhu Institute for Drug Control,Wuhu,Anhui Province 241001);Determination of bromhexine hydrochloride injection and its related substances by HPLC[J];Anhui Medical and Pharmaceutical Journal;2008-02
3 YANG Jian-lin(Huainan Institute for Food and Drug Control,Huainan 232007,China);Determination of promethazine hydrochloride in tablets of fu fang luobuma Ⅱ by RP-HPLC[J];Anhui Medical and Pharmaceutical Journal;2009-02
4 Wu Yanlin Lin Zhihua (Wuhan Institute for Drug Control,Wuhan 430012,China); Wang Yang (College of pharmacy,Tongji Medical College,Huazhong University of Science and Technology); Chen Shihui (Xianning Medical College);Determination the Contents of Four Components in Compound Reserpine Tablets by HPLC[J];China Pharmacist;2007-06
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