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《Journal of Guangdong Pharmaceutical College》 2009-01
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The experimental study on anti-inflammatory and analgesic effectsof Qidan Granules in treatment of endometriosis

JIANG Tao1,CHU Bo1,TANG Chun-ping1,YANG Chao-yan1,LU Wei-gen2,ZENG Zhao-zhi1,ZHANG Jin-hong1(1.Guangdong Pharmaceutical College,Guangzhou,Guangdong 510006,China;2.Shanghai Institute of Pharma-ceutical Industry,Shanghai 200040,China)  
Objective To explore the pharmacological effects of Qidan Granules in the treatment of endometriosis.Methods Different animal models were established to observe the anti-inflammatory and analgesic effects of Qidan Granules.The animal models included dimethylbenzene-induced acute ear swelling in mice,carrageen-induced toe swelling and cotton pellet-induced granuloma in rats,increased capillary permeability induced by acetic acid;pain experiments induced by hot plate and glacial acetic acid,and oxytocin-induced dysmenorrhea in mice.Results Qidan Granules could relieve the pain caused by glacial acetic acid and heat stimuli;significantly inhibit the oxytocin-induced dysmenorrheal in mice;It also showed obvious inhibitory effects on the increased capillary permeability induced by glacial acetic acid,carrageen-induced toe edema in rats and dimethylbenzene-induced ear swelling in mice,and cotton pellet-induced granuloma formation in rats.It could also significantly inhibit oxytocin-induced dysmenorrhea in mice.Conclusion Qidan Granules showed markedly anti-inflammatory and analgesic effects in the study,providing the basis for the clinical utilization in the treatment of endometriosis.
【Fund】: 上海市科委资助项目(05DZ19707)
【CateGory Index】: R285.5
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