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《Journal of Guangdong Pharmaceutical College》 2009-02
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Active constituents from Gardenia jasminoides against acute lymphoblastic leukemia

REN Qiang,SUN Li-hua,LIU Xin-min,LIU Chun-yu,QUAN Li-hui,XIE Chen,LIAO Yong-hong(Institute of Medicinal Plant Development,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing 100193,China)  
Objective To determine the active constituents from Gardenia jasminoides against acute lymphoblastic leukemia.Methods Compounds were isolated and purified by various column chromatographic techniques and their structures were elucidated on the basis of spectral analysis(IR,ESI-MS,1H-NMR,13C-NMR).The inhibitory activity against the proliferation of HL-60,REH and Raji cell lines was determined by using MTT assay.Results Eight compounds were isolated and identified as β-sitosterol(1),5-hydroxy-7,3′,4′,5′-tetramethoxyflavone(2),Ursolic acid(3),D-mannitol(4),geniposide(5),deacetylasperulosidic acid methyl ester(6),genipin-1-β-gentiobioside(7) and scandoside methyl ester(8).Compound 3 exhibited inhibitory effects on leukemic cell proliferation in vitro with IC50 of 12.2,7.5 and 15.4 μg/mL aginst HL-60,REH and Raji cell lines,respectively.Conclusion Ursolic acid might be one of the active ingredients against anti-acute lymphoblastic leukemia conferred by Gardenia jasminoides Ellis.
【Fund】: 863计划重点项目资助(2006AA02Z4Z2)
【CateGory Index】: R284
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