Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Guangdong Pharmaceutical College》 2011-01
Add to Favorite Get Latest Update

Determination of the apparent oil-water partition coefficient and serum protein binding rate of Bajijiasu

CHEN Yong-gang1,LIN Li2,WU Jin-hu1(1.Department of Pharmacy,The Third Hospital of Wuhan,Wuhan,Hubei 430060,China;2.Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510006,China)  
Objective To determine the apparent oil-water partition coefficient and serum protein binding rate of Bajijiasu which might support for its pharmacokinetics research in vivo.Methods HPLC-ELSD was used for the assay of Bajijiasu,and the partition coefficients were determined by shaking flask method.The ultrafiltration method was employed to obtain the serum protein binding rates.Results The apparent oil-water partition coefficient in octanol/water system was 0.052 5(logρapp=-1.28) and 0.050 7(logρapp=-1.295) in octanol/phosphate buffer(pH=6.8) system.The serum protein binding rates of Bajijiasu with BSA,HSA and rat serum protein were 42.15%、40.67%、30.89%,respectively.Conclusion Bajijiasu was a hydrotropic substance.The partition coefficients in octanol/water system is identical with octanol/ phosphate buffer(pH=6.8) system.The serum protein binding rate of Bajijiasu with BSA、HAS was significantly higher than other rat serum protein,which showed that Bajijiasu may have a kind of specific binding with albumin in serum.
【Fund】: 海南省重点科技项目(090603)
【CateGory Index】: R284.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 9 Hits
1 CHEN Jiewen, WANG Yong, TAN Baoxuan, CHEN Chaofeng (Dept. of Physiology, Guangzhou University of TCM, Guangzhou 510405,China);Neuroactivities Basis of BA-JI-SU in Invigorating Kidney to Improve Mental Power[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1999-04
2 yang Xiao Feng-xia,Lin Li(College of Chinese Traditional Medicine,Guangzhou University of TCM,Guangzhou 510405,China);A preliminary study on the effect of Morinda officinalis How on invigorating the kidney and strengthening[J];Food and Drug;2006-05
3 LIANG Hong-yu,WU Wei,CHEN Hong-gui (Second Traditional Chinese Hospital of Guangdong Province,Guangzhou 510095,China );The preliminary study of bajisu impr oving language function in treating vascular dementia[J];Modern Rehabilitation;2001-21
4 WANG Xiao-yang,XIE Ren-ming,SUN Wen-ji(Biology and Medicine Key Laboratory of Shaanxi Province,Northwest University,Xi'an 710069,China);Determination of equilibrium solubility and apparent oil/water partition coefficient of epimedin C[J];Chinese Journal of Pharmaceutical Analysis;2010-08
5 JING Chun-jie1, 2, CHEN Xiao-hui1, LIU Xuan2, BI Kai-shun1, GUO De-an2 (1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China);Determination of the binding rate of rat plasma protein with salvianolic acid B[J];Acta Pharmaceutica Sinica;2010-03
6 ZHANG Qianyi1,DU Shouying1,LU Yang1,RAO Xiuli2(School of Chinese Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing 100102,China);Studies on O/W partition coefficient and absorption kinetics of geniposide in fructus gardeniae extract in rat intestine[J];China Journal of Chinese Materia Medica;2009-14
7 LIN Fang-hua,LIN Li,XIAO Feng-xia,LIU Xiao-han,WANG Jin-yu(College of Chinese Medicine,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China);Effect of Bajijiasu on mating capability and immune organ coefficients in healthy male mice[J];Chinese Journal of New Drugs;2008-22
8 YE Yong1,2,ZHOU Li-ling1,YAN Yi-lin3,HUANG Qiu-jie4(1.Guangzhou University of Chinese Medicine,Guangzhou 510006,China;2.Guangxi Medical University,Nanning 530021,China;3.Guangdong Food and Drug Vocational College,Guangzhou 510520,China;4.Guangxi University of TCM,Nanning 530001,China);Determination of Plasma Protein Binding Rate of Tetramethylpyrazine Phosphate by Ultrafiltration[J];Journal of Chinese Medicinal Materials;2010-08
9 Tan BaoXuan,Su wen,Chen Jiewen (Department of Physiology,Guangzhou University of TCM,Guangzhou 510405);Improvement Effect of Bajishin on Spatial Learning and Memory Abiligy of Rats[J];TRADITIONAL CHINESE DRUG RESEARCH & CLINICAL PHARMACOLOGY;2000-02
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Ya-le1,2,JIA Xiao-bin1,2,CHEN Yan1,LI Xia1(1Key Laboratory of New Drug Delivery System of Traditional Chinese Medicine and Applied Technology,Jiangsu Provincial Academy of Chinese Medicine,Nanjing 210028,China;2Jiansu University,Zhenjiang 212013,China);Determination of equilibrium solubility of icariin and its apparent oil/water partition coefficient[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-09
2 MO Zhi-xian1, PENG Lin-guang2, PENG Wang11Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; 2Zhongluo- tan Hospital of Baiyun District, Guangzhou 510550, China;Effects of Emu eggshell on sexual function of male mice[J];Journal of First Military Medical University;2005-02
3 LIU Ming~1,CHEN Shu-ye~2,YANG Tian-fu~(1*),XU Xiao-hong~2(1.Department of Orthopaedics,West China Hospital,Sichuan University,Chengdu 610041,China;2.West China School of Pharmacy,Sichuan University,Chengdu 610041,China);The absorption kinetics of Piperazine ferulate in various intestinal segments of rat[J];West China Journal of Pharmaceutical Sciences;2006-04
4 Ting Jian Xie Xiaping Wang Tianyou Ding Aishi Wang Fuzhuang( Institute of Basic Medial Science , AMMS, Beijing, and Beijing Neurosurgieal Insitute, Beijing );The Resistance of Rat Hippocampal Slices to Hypoxia in Vitro[J];Basic Medical Sciences and Clinics;1992-03
5 CHEN ZhongFANG DainanJI Minghui (Dept. of Biology, Hainan Normal University,Haikou 571158, China);Effect of Morinda officinalis How Decoction on Immune Function in Mice[J];Bulletin of Science and Technology;2003-03
6 Lin Li Xu Honghua Wang Shuyin Feng Xianxiang Faculty of Chinese Pharmacology;Quantitative Analysis of Trace Elements,Amimo-acids and Sugar in Radix Morinda Officinalis of Different Growth Age[J];;1992-03
7 CHEN Jiewen, WANG Yong, TAN Baoxuan, CHEN Chaofeng (Dept. of Physiology, Guangzhou University of TCM, Guangzhou 510405,China);Neuroactivities Basis of BA-JI-SU in Invigorating Kidney to Improve Mental Power[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1999-04
8 Chen Jiewen Tan Baoxuan Su Wen Dept. of Physiology,Guangzhou University of TCM 510407;The Protective Effect of Ilexonin A on Neurons of Rat Hippocampus in Hypoxic Injury and Its Mechanism[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1997-02
9 yang Xiao Feng-xia,Lin Li(College of Chinese Traditional Medicine,Guangzhou University of TCM,Guangzhou 510405,China);A preliminary study on the effect of Morinda officinalis How on invigorating the kidney and strengthening[J];Food and Drug;2006-05
10 WANG Shou chun,SUN Li,ZHANG Yu. The First Clinical Hospital of Norman Bethune University of Medical Sceinces,Changchun 130021,China;The effect of yizhi oral liquid on the learnign and memory of chronic cerebral inchemic dementia rat[J];Modern Rehabilitation;2001-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved