Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Guangdong Pharmaceutical University》 2012-04
Add to Favorite Get Latest Update

The research progresses of the PK-PD modeling

ZENG Jie,WANG Su-jun,YANG Ben-kun,Mo Li-li(Clinical Pharmacy Department,Guangdong Pharmaceutical University,Guangzhou 510006,China)  
The pharmacokinetic-pharmacodynamic(PK-PD) model,linking dose-concentration relationship and concentration-effect relationship,facilitates the description and prediction of the time course of drug effects resulting from a certain dosing regimen.Four types of PK-PD models have been distinguished,including direct-link versus indirect-link model,direct-response versus indirect-response model,soft-link versus hard-link model and time-variant versus time-invariant model.PK-PD model has been widely applied in preclinical and clinical drug development,such as formulation of dosage,the estimate of drug safety and efficacy.In the present paper,the classification and research progress of the PK-PD model are reviewed.
【Fund】: 国家自然科学基金(81073141);; 广东省自然科学基金(9152402301000007);; 广东省医学科学技术研究基金(A2009317)
【CateGory Index】: R969.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved