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《Journal of Guangdong Medical College》 2009-04
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Effect of the combination of allicin and acyclovir on relapse prevention of the recurrent genital herpes and serum IL-2 and IFN-γ level

DU De-rong1,LIU Ru-qing2 (1.Department of Dermatology,Dongsheng Hospital of Guangzhou,Guangzhou 510120,China;2.Public Hygiene School of Zhongshan University,Guangzhou 510120,China)  
Objective To observe the effect of combination of allicin and acyclovir on the relapse prevention of recurrent genital herpes(RGH) and serum IL-2 and IFN-γ levels.Methods Eighty-four RGH patients were randomly divided into allicin + acyclovir group and acyclovir group,each 42 cases.The relapse rate and recurrent symptoms were recorded within a year after the treatment.Serum levels of IL-2 and IFN-γ were determined by ELISA.Results The relapse rate in allicin + acyclovir group was significantly lower than that in acyclovir group [(1.02±0.78) vs(2.94±0.92),P0.01].Serum levels of IL-2 and IFN-γ increased significantly after the treatment with allicin + acyclovir than before the treatment,and than after the treatment with acyclovir alone(P0.05).There were no statistical differences between the pre-and post-treatment with acyclovir alone(P0.05).Conclusion Combined treatment with allicin + acyclovir can reduce the relapse rate and improve the cellular immunity in RGH patients.
【CateGory Index】: R752.1
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