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《Journal of Guangdong Medical College》 2009-06
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Anti-inflammatory mechanism of luteolin in-vivo

ZHANG Yi,WANG Xu-guang,YAN Zhang,HE Hui-juan (Guangdong Medical College,Zhangjian 524001,China)  
Objective To investigate the anti-inflammatory effect and mechanism of luteolin in-vivo.Methods The model of carrageenan-induced edema of rat hind paws was prepared.The edema model was treated with luteolin and dexamethasone(for a positive control).The PGE2 content in the edema exudate was measured by EIA.The COX-2 expression of the edema paws was detected by immunohistochemistry and Western blot.Results Luteolin reduced the paw edema,the PGE2 contents in the exudate and the COX-2 protein expression in the edema paws.Conclusion Luteolin has an anti-inflammatory effect on rat inflammation induced by carrageenan probably through the mechanisms of the inhibition of COX-2 protein expression and of PGE2 production.
【Fund】: 广东省中医药局科研项目(No.2007131)
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Yi,WANG Xuguang(Central Laboratory,Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001 Guangdong,China);Studies on In-vitro Anti-inflammatory Mechanism of Luteolin[J];Journal of Guangzhou University of Traditional Chinese Medicine;2007-03
2 WANG Xu-guang,CHEN Gen-yin,CHEN Miao-ping(First Affiliated Hospital of Guangdong Medical College,Zhanjiang 524100,China);Effect of Luteolin on COX-2 and mPGES-1 Expression in LPS-induced RAW264.7 Cells[J];Journal of Chinese Medicinal Materials;2007-10
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 WANG Zheng-dong,HUANG Mao,FAN Wen-hui,ZUO Zhi-yuan,YIN Kai-sheng(Department of Respiratory,the First Affiliated Hospital of NJMU,Nanjing,210029,China);Effect of luteolin on expression of IL-13Rα2 in the airway of asthmatic mice with airway remodeling[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2007-05
2 YANG Yan,LI Li-li,HUANG Mao(Department of Respiratory Medicine,the First Affiliated Hospital of Nanjing Medical University,210029,Nanjing,China);Effects of Luteolin on the Expression of Transcription Factor GATA-3 in Asthmatic Mice[J];Progress in Modern Biomedicine;2009-04
3 TANG Ning1,2,LI Zi-yan1,ZHOU Yong-mei1,LIU Bao-lin11 Department of Pharmacology of Chinese Material Medica,China Pharmaceutical University,Nanjing 210038,Jiangsu,China;2Life Science Department,Nanjing Xiaozhuang College,Nanjing 211171,Jiangsu,China;Evaluation of anti-inflammatory effects of luteolin and underlying mechanisems[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2007-02
4 CHEN Hong-mei1,LI Yan-jing1,WANG Jin-ke2,LI Ping11Department of Pharmacognosy, China Pharmaceutical University,Nanjing 210038,China;2State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China;Advances in regulation of nuclear factor-κB activation by traditional Chinese medicines[J];Pharmaceutical and Clinical Research;2008-02
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