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Anti-inflammatory mechanism of luteolin in-vivo

ZHANG Yi,WANG Xu-guang,YAN Zhang,HE Hui-juan (Guangdong Medical College,Zhangjian 524001,China)  
Objective To investigate the anti-inflammatory effect and mechanism of luteolin in-vivo.Methods The model of carrageenan-induced edema of rat hind paws was prepared.The edema model was treated with luteolin and dexamethasone(for a positive control).The PGE2 content in the edema exudate was measured by EIA.The COX-2 expression of the edema paws was detected by immunohistochemistry and Western blot.Results Luteolin reduced the paw edema,the PGE2 contents in the exudate and the COX-2 protein expression in the edema paws.Conclusion Luteolin has an anti-inflammatory effect on rat inflammation induced by carrageenan probably through the mechanisms of the inhibition of COX-2 protein expression and of PGE2 production.
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