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《Acta Polymerica Sinica》 2002-06
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THE BIOACTIVITY OF PAMAM DENDRIMERS MODIFIED WITH PEPTIDES

ZHONG Hong, JIA Xinru, LUO Yufei, CHEN Lirong (College of Chemistry and Molecular Engineering, Peking University, Beijing 100871) WEI Yen (Department of Chemistry, Drexel University, Philadelphia PA 19104)  
The peptides of Gly-Asp,Gly-Asp-Gly-Asp and Gly-Asp-(Gly-Asp) 2 were synthesized.These peptides and Asp were introduced at the periphery of G3.5 PAMAM dendrimers,respectively.It was found by calculating from 1H integrations of each modified compound that 77%,60%,24% and 18% of ester groups on the surface of these dendrimers reacted with the Asp、Gly-Asp,Gly-Asp-Gly-Asp and Gly-Asp-(Gly-Asp) 2 peptides,respectively.The molecular simulating showed that the conformation of Gly-Asp-(Gly-Asp) 2 is quite similar to β-sheets.Compared with PAMAMC,these modified PAMAM dendrimers could obviously decrease the reduction rate of Fe Ⅲ-cyt c by ascorbic acid,especially,the dendrimer with Gly-Asp-(Gly-Asp) 2 on its exterrior. The experimental results demonstrated the better recognition and affinity between the peptides modified PAMAM dendrimers and Cytochrome C.The association constant of G3.5-Gly-Asp-(Gly-Asp) 2 with cytochrome C is 1.6×10 5.
【Fund】: 国家自然科学基金资助项目 (基金号 5 99730 0 1)
【CateGory Index】: TQ323
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