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《Acta Polymerica Sinica》 2010-04
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SYNTHESIS OF TERPYRIDINE-FUNCTIONALIZED POLY(N-ISOPROPYLACYLAMIDE)S AND THEIR METAL COMPLEXES

SUN Peijian1,2,SHI Xudong1,GAN Zhihua1 (1 CAS Key Laboratory of Engineering Plastics,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190) (2 Graduate University of Chinese Academy of Sciences,Beijing 100039)  
A new terpyridine-functionalized dithioester was synthesized as a chain transfer agent in the reversible addition fragmentation chain transfer polymerization ( RAFT) of N-isopropylacyamide ( NIPAAm). The polymerization showed an first-order kinetics and the molecular weight increased linearly with conversion,indicating that the terpyridine-functionalized dithioester is an efficient chain transfer agent for the RAFT polymerization of NIPAAm. The terpyridine-functionalized poly ( N-isopropylacyamide) ( tpy-PNIPAAm) not only displays similar phase transition as PNIPAAm,but also have the coordination ability via terpyridine,which were further used to construct macromolecular-metal complex with ferrous ions as model metal ions. The appearance of a strong absorption at 555 nm in UV-Vis spectrum revealed the formation of macromolecular-metal complex,indicating the strong coordination ability of tpy-PNIPAAm to metal. Cloud point method and dynamic light scattering ( DLS ) were used to characterize the thermosensitivity of tpy-PNIPAAm and macromolecular-metal complex. The results showed that the macromolecular-metal complex could self-assemble into nanoparticles in aqueous solution due to the amphiphilic property The macromolecular-metal complex solution showed a similar phase transition as PNIPAAm. In addition,the nanoparticles of the macromolecular-metal complex in aqueous solution were stable even at temperature above the lower critical solution temperature (LCST) due to electrostatic repulsion. This work indicated the great potentials of tpy-PNIPAAm as carriers for the delivery of therapeutic radioisotopes.
【Fund】: 国家自然科学基金(基金号50873109 50830103);; 中国科学院知识创新工程重要方向项目(项目号KJCX2-YW-H19)资助
【CateGory Index】: O633.5
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