Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Polymerica Sinica》 2012-07
Add to Favorite Get Latest Update

BIODEGRADABLE THERMO-SENSITIVE HYDROGELS FOR CONTROLLED DELIVERY OF PARATHYROID HORMONE RELATED PEPTIDE

Cong Li1,Zhe Zhang3,Chao-liang He2,Xiu-li Zhuang2,Li Chen3,Qing Cai1,Yan Xue1, Bin Zhang1,Shi-zhen Wang1,Wei-yan Meng1,Xue-si Chen2(1 School of Stomatology,Jilin University,Changchun 130021)(2 Changchun Institute of Applied Chemistry,State Key Laboratory of Polymer Physics and Chemistry,Changchun 130022)(3 College of Chemistry,Northeast Normal University,Changchun 130024)  
A series of thermo-sensitive hydrogels were designed and synthesized via radical polymerization of N-isopropylacrylamide(NIPAAm) by using a biodegradable acryloyl-poly(ε-caprolactone)-2-hydroxylethyl methacrylate(AC-PCL-HEMA) as a cross-linker.The influence of temperature on the equilibrium swelling ratio and the optical transmittance of the hydrogel was studied.The in vitro release of parathyroid hormone related peptide(PTHrP) which can increase the number and viability of osteoblasts and promote bone formation,from the hydrogel was investigated.The release profiles indicated that the sustained release of PTHrP from the smart hydrogel was over 13 days,indicating that the materials have potential applications in the field of oral implantology.
【Fund】: 国家自然科学基金(基金号50973108 51003103和21174142);; 科技部国际合作与交流专项(项目号2010DFB50890);; 吉林省科技发展计划(项目号201101082和20110332)资助项目
【CateGory Index】: R783
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved