Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《高分子科学(英文版)》 2010-05
Add to Favorite Get Latest Update

INITIATOR-FREE PHOTOCROSSLINKING OF ELECTROSPUN BIODEGRADABLE POLYESTER FIBER BASED TUBULAR SCAFFOLDS AND THEIR CELL AFFINITY FOR VASCULAR TISSUE ENGINEERING

Lin Ye~b,Xin Wu~(a+),Xue Geng~b,Yong-hong Duan~a,Yong-quan Gu~a,Ai-ying Zhang~b, Jian Zhang~(a**) and Zeng-guo Feng~(b**) a Xuanwu Hospital,Capital Medical University,Beijing 100053,China b School of Materials Science and Engineering,Beijing Institute of Technology,Beijing 100081,China  
Random copolyester of poly(ε-caprolactone-co-L-lactide)(PCLA) with a 50:50 feeding molar ratio was synthesized via the ring-opening polymerization and functionalized by the end-capping reaction with acryloyl chloride.The resulting acrylated PCLA was then fabricated into small diameter tubular scaffolds by electrospinning technique and the formed scaffolds were followed by photocrosslinking under UV irradiation in the absence of photoinitiator.The mechanical strengths including tensile,suture retention and burst pressure were greatly enhanced after the photocrosslinking.The in vitro degradation data clearly revealed that the mechanical properties of the crosslinked scaffolds still remained after one month degradation in PBS solution,while those of the non-crosslinked ones lost heavily.The cytotoxicity assay on the mouse fibroblast L929 cells was conducted via MTT measurement.Furthermore,the observation on endothelial and fibroblast cell adhesion and proliferation was also made by using scanning electron microscopy(SEM).The initiator-free photocrosslinked tubular scaffolds show the potential to be used in vascular tissue engineering.
【Fund】: supported by the‘863' Project of Minister of Science and Technology of China(Nos.2006AA02A134 and 2007AA021905);; basic research foundation of Beijing Institute of Technology(No. 20080942001).
【CateGory Index】: O631
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved