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《高分子科学(英文版)》 2011-02
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THE AMPHIPHILIC MULTIARM COPOLYMERS BASED ON HYPERBRANCHED POLYESTER AND LYSINE:SYNTHESIS AND SELF-ASSEMBLY

Jing Wang~a,Yuan Yao~a,Bing Ji~b,Wei Huang~(a**),Yong-feng Zhou~a and De-yue Yan~a a School of Chemistry and Chemical Engineering,State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University,Shanghai 200240,China b Huzhou Teachers College,Huzhou 313000,China  
The amphiphilic multiarm copolymers were synthesized through the modification of commercially available hyperbranched polyesters(Boltorn H40) with N-ε-carbobenzoxy-L-Lysine N-carboxyanhydride(ZLys-NCA).After being condensed with N-Boc-phenylalanine(Boc-~NPhe) and deprotected the Boc-groups in trifluoroacetic acid(TFA),the original terminal hydroxyl groups were transformed into the amino groups and then initiated the ring-opening polymerization of ZLys-NCA.The hydrophilic poly(L-lysine) was grafted to the surface of Boltorn H40 successfully after the protecting benzyl groups were removed by the HBr solution in glacial acetic acid(33 wt%).The resulting multiarm copolymers were characterized by the ~1H-NMR,GPC and FTIR.The arm length calculated by NMR and GPC analysis was about 3 and 13 lysine-units for H40-Phe-PLysl and H40-Phe-PLys2 respectively.Due to the amphiphilic molecular structure,they displayed ability to self-assemble into spherical micelles in aqueous solution with the average diameter in the range from 70 nm to 250 nm.The CMC of H40-Phe-PLysl and H40-Phe-PLys2 was 0.013 mg/mL and 0.028 mg/mL,respectively, indicating that H40-Phe-PLysl with shorter arm length is easier to self-assemble than H40-Phe-PLys2 with longer arm length.
【Fund】: supported by the National Basic Research Program(Nos.2007CB808000 2009CB930400);; the National Natural Science Foundation of China(Nos.50873058 20874060 50633010);; Shanghai Leading Academic Discipline Project(No.B202);; the Zhejiang Provincial Natural Science Foundation of China(No.Y405411)
【CateGory Index】: O631.3
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