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《Polymer Bulletin》 2020-03
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The Effects Condition on the Nanofibrous Structures of Poly(lactic acid)/ Chitosan Scaffolds and Bio-mineralization Activity

LIU Shu-qiong;WU Fang-fang;WU Fang-di;Lü Zhi-yu;Fujian Provincial Key laboratory of Eco-Industrial Green Technology, College of Ecological and Resources Engineering, Wuyi University;  
Poly(lactic acid)(PLA)/chitosan(CS) composite nanofibrous scaffolds were fabricated from a quaternary PLA/CS/dioxane/glacial acetic acid system by phase separation method. The effects of gelation temperature, CS content and the molecular weight of PLA on the morphology of composite scaffolds were investigated. The results revealed that gelation temperature and the molecular weight of PLA significantly influenced the formation of nanofibrous structure, but the CS content had very litter effect on the nanofibrous structure. The microstructure of the PLA/CS composite scaffolds changed greatly with the reduction of gelation temperature, from nano-structure to micro-structure. Besides, high molecular weight of PLA make for nanofibrous structure easier than the low molecular weight of PLA in this work. The mineralization results showed that PLA/CS composite nanofibrous scaffolds could induce hydroxyapatite formation faster than pure PLA nanofibrous scaffolds.
【Fund】: 福建省生态产业绿色技术重点实验室开放课题(WYKF2018-12);; 福建省大学生创新创业训练项目(201810397037 201910397034)
【CateGory Index】: R318.08;TQ342
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1 YANG Shenyu;TANG Sanyuan;TAM Manseng;ZENG Rong;YANG Hui;HUANG Hsiungpei;HA Katsang;TU Mei;Department of Materials Science and Engineering, Jinan University;Zhuhai People's Hospital;Centro Medico Ian Wo;Centro Hospitalar Conde de S?o Januário;;Surface Modification of Hydroxyapatite-Grafted-Chitosan and Biocompatibility Evaluation of CS/HA-G-CS Composite Hydrogel[J];材料研究学报;2015-11
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