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《Polymer Bulletin》 2020-03
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The Effects Condition on the Nanofibrous Structures of Poly(lactic acid)/ Chitosan Scaffolds and Bio-mineralization Activity

LIU Shu-qiong;WU Fang-fang;WU Fang-di;Lü Zhi-yu;Fujian Provincial Key laboratory of Eco-Industrial Green Technology, College of Ecological and Resources Engineering, Wuyi University;  
Poly(lactic acid)(PLA)/chitosan(CS) composite nanofibrous scaffolds were fabricated from a quaternary PLA/CS/dioxane/glacial acetic acid system by phase separation method. The effects of gelation temperature, CS content and the molecular weight of PLA on the morphology of composite scaffolds were investigated. The results revealed that gelation temperature and the molecular weight of PLA significantly influenced the formation of nanofibrous structure, but the CS content had very litter effect on the nanofibrous structure. The microstructure of the PLA/CS composite scaffolds changed greatly with the reduction of gelation temperature, from nano-structure to micro-structure. Besides, high molecular weight of PLA make for nanofibrous structure easier than the low molecular weight of PLA in this work. The mineralization results showed that PLA/CS composite nanofibrous scaffolds could induce hydroxyapatite formation faster than pure PLA nanofibrous scaffolds.
【Fund】: 福建省生态产业绿色技术重点实验室开放课题(WYKF2018-12);; 福建省大学生创新创业训练项目(201810397037 201910397034)
【CateGory Index】: R318.08;TQ342
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 YANG Shenyu;TANG Sanyuan;TAM Manseng;ZENG Rong;YANG Hui;HUANG Hsiungpei;HA Katsang;TU Mei;Department of Materials Science and Engineering, Jinan University;Zhuhai People's Hospital;Centro Medico Ian Wo;Centro Hospitalar Conde de S?o Januário;;Surface Modification of Hydroxyapatite-Grafted-Chitosan and Biocompatibility Evaluation of CS/HA-G-CS Composite Hydrogel[J];材料研究学报;2015-11
2 LI Li-hua,DING Shan,ZHOU Chang-ren(Department of Material Science and Engineering,Engineering Research Center of Artificial Organs and Materials,Ji'nan University,Guangzhou 510632,China);A rapid,facile and efficient biomineralization approach for chitosan materials[J];功能材料;2010-11
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 ZHAO Yao-wu1,2,ZHAO Ming-yan2,3,LI Li-hua2,3,LI Hong2,3,LI Bo2,3,LU Lu2,3,ZHOU Chang-ren2,3(1.Department of Stomatology of Medical College,Jinan University,Guangzhou 510632,China; 2.Department of Material Science and Engineering,Jinan University,Guangzhou 510632,China; 3.Engineering Research Center of Artificial Organs and Materials,Jinan University,Guangzhou 510632,China);Preparation and characterization of calcium alginate hydrogels as occlusion of dentinal tubules[J];功能材料;2012-07
2 DING Shan,TANG Min-jian,ZHOU Chang-ren,TIAN Jin-huan,LI Li-hua(Department of Material Science and Engineering,Jinan University;Engineering Research Center of Artificial Organs and Materials,Ministry of Education,Guangzhou 510632,China);Synthesis and mineralization behavior study of bionic functional chitosan[J];功能材料;2012-02
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Xiang-nan1,2,CHEN Xiao-ming1,PENG Zhi-ming1,LI Shi-pu1(1.Biomedical Materials and Engineering Research Center, Wuhan University of Technology,Wuhan 430070,China; 2.College of Chemical Engineering,Wuhan University of Technology,Wuhan 430070,China);Preparation and characterization of hollow hydroxyapatite submicrospheres/chitosan injectable hydrogels[J];功能材料;2011-02
2 LI Zhanyong; SHI Linqi; WANG Changfeng; HE Binglin; LIANG Shuren(1 The State Key Laboratory of Polymer Polymer Materials for Adsorption and SeparationInstitute of polymer Chemistry, Nankai University, Tianjin 300071,2 Tianjin Infectious Disease Hospital,;STUDIES ON THE PREPARATION OF CROSSLINKED CHITOSAN RESIN AND ITS BLOOD COMPATIBILITY[J];离子交换与吸附;1999-05
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