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《The Journal of Bone and Joint Injury》 1999-04
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An Experimental Research of Corticosteroids to ANFH Used for a Long Time or a Short Time with an Ultra-Dose

Li Xiong, YuanHao, Bei Meilian, et al. Clinic and Research Center, The First Affiliated Hospital, Guangzhou University of TCM, Guang zhou , 510405.  
Authors research the different effect to animal body and aseptic necrosis of femoral head (ANFH) after being injected corticosteroids for a long time or a short time with an ultradose, which can provide an experimental basis and warn the necessarity to prevent GANFH. Twenty - one adult SD rats were divided into three groups. Group first consisted of seven animals that received an gultaeus muscle injection of 49 mg/kg.d, prenisoloni Acetatis for six consecutive days. Group second consisted of seven rats that received an glutaeus muscle injection of 24.5 mg/kg prenisoloni Acetatis once a week for twelve consecutive weeks. The total dose of group first and second was 294 mg/kg equally. Group third com-prised seven rats that received isotonic saline. All animals were observed about their reaction, gross and microscopy mani-festation of viscera and femoral head, a statistics about the rate of empty lacunae. Results showed:①The reflection of body and manifestation of gross viscera of group first were worse than those of group second.②The display of ANFH and the rate of empty lacunae of body and manifestation of gross viscera of short-time group were worse than those of long -time group.② The display of ANFH and the rate of empty lacunae in long - time group were worse than that in short -time group, there were significant difference between two groups (P0. 01). Conclusion: ①The toxicity and by - ef-fect of ultradose corticosteroids were giant.②The damage to vascular system of the whole body for overdose corticos-teroids is accordance with that to blood vessel in femoral head.③GANFH can be brought out by corticosteroids solely.④ The treatment that a ultradose corticosteroids in a short time or a overdose corticosteroids in a long time can promote the development of GANFH. Therefore, we must emphasize the prevention of GANFH.
【CateGory Index】: R681.8
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