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《The Journal of Bone and Joint Injury》 2000-03
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Experimental Study of bBMP/Collagen/Coral Composited Bone Substitute in Repairing of Bone Defect of Femoral Head

Xu Xiaoliang,Tong zhi qin,Wang Kunzhen et al.Department of Orthopedics,The Second Affiliated Hospital of Xi'an Medical University,Xi'an,710004.  
Objective To evaluate the effectiveness of bBMP/collagen/coral composited bone substitute in treatment of avascular necrosis of the femoral head(ANFH).Methods Animal model of bone defect of canine bilateral femoral heads were established.They were divided into 4 groups:①composited bone substitute group(n=6),②muscle pedicle bone group(n=6),③simple coral group(n=2),④control group:contralateral hip(n=14).Pathological examination was studied at 3 weeks and tetracycline labelling,metrical histological analysis were studied at 16 weeks.Results At 16 weeks,there were statistically significant differences of the size of bone defect,trabecular bone volume and width of tetracycline fluorescent zone between composited bone substitute group and control group.one of 5 cases of bone substitute group developed secondary osteoarthritis.Conclusions The composited bone substitute possesses a superior osteoinductivity and osteoconductivity in repairing of bone defect of femoral head,but it can't improve the revascularization of ANFH.The bone defect model of femoral head is similar to cystic change of ANFH and can be used in the study of treatment of ANFH.
【CateGory Index】: R687
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