Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《The Journal of Bone and Joint Injury》 2001-05
Add to Favorite Get Latest Update

The Experimental Research of Alteration of Bone Metabolism in Steroid-induced Necrosis of Femoral Head

Hong Jiayuan,Guo Linxin,Kang Liangqi et al.Department of Orthopaedics, The 175th Hospital of PLA,Zhangzhou Fujian City,363000.  
Objective To study the mechanism of bone metabolism of steroid-induced necrosis of femoral head(SINFH).Methods Thirty male New Zealand rabbits were randomly divided into two groups:normal control group and model group.A model of SINFH was induce by intramuscularly hydrocortisone acetate overdose.The hydroxyproline(HOP),hexosamine(HOM) and calcium(Ca) of femoral head and serum-calcium, serum-phosphorous were measured and the ratio of HOM/HOP, Ca/HOP and the serum-calcium-phosphorous-product were calculated every two weeks, as well as the X-ray and histopathology of femoral head observed.Results It showed HOP, HOM, Ca and the ratio of HOM/HOP, Ca/HOP of femoral head of model group obviously lower than control group as well as the serum-calcium and serum-calcium-phosphorous-product were obviously lower than control grorp.The X-ray showed the model group became osteoporosis and the histopathology showed the ratio of empty lacunae and the diameters of fat cell in medullae of model group increased obviously(P0.01),otherwise the diameters of trabecula decreased obviously. Conclusion Overdose steroid can induce early necrosis of femoral head.The alteration of bone metabolism caused by overdose steroid was one of the complex factors of SINFH.
【Fund】: 福建省自然科学基金资助项目 (C950 39)
【CateGory Index】: R681.8
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved